Copper–catalyzed carbene insertion/ester migration/cyclization of enaminones and α-diazo compounds occurred efficiently, affording 2-ester polysubstituted pyrroles under mild conditions in moderate to good yields. Substituents functionality are well tolerated and 13C-labelled...
Herein, both homogeneous and heterogeneous strategies were developed to access highly functionalized 3H-1,2,4-triazines using Cu-catalyzed [4 + 2] annulation.
Amino compounds have a wide range of applications in the fields of organic chemistry, medicinal chemistry and functional materials. The efficient construction of C-N bonds has important research significance. Conventional amination reactions to construct C-N bonds require pre-functionalization of the substrate and inevitably produce quantitative halogenate by-products. The C-H amination reaction is directly based on hydrocarbons. The reaction has the advantages of "step" and "atomic" economy, in line with the green chemistry concept. Transition metal cobalt has the advantage of low toxicity and low cost. As a catalyst for C-H amination reaction, it exhibits its unique catalytic properties and attracts the attention of chemists. The research progress of cobalt-catalyzed C-H amination in recent years is summarized. At the same time, the challenges and development prospects of the research field are summarized and forecasted.
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