These results suggest that OPG plays a role in preserving myocardial structure and function with ageing through a reduction in apoptosis and preservation of the matrix structure. In addition, this appears to be independent of effects on the vasculature.

SummaryOsteoprotegerin plays a critical role in angiotensin II-induced cardiac remodeling, and lack of this gene leads to dilate left ventricular chamber, resulting in functional left ventricular decompensation.

It is debated whether carbohydrate restriction has metabolic advantage for its variable weight loss. Five-week-old male mice fed a high-fat diet receiving a glycolytic inhibitor, 2-deoxyglucose, led to an absolute mortality within 9 days. They exhibited greater decreases in rectal temperature, appetite and decline in body weight accompanied by increasing total cholesterol level than the other groups. This study suggests that carbohydrate is necessary for adequate physical and metabolic performance when lipid-rich diet is loaded.

No abstract