Migraine is a chronic disease which affects approximately 12-18% of the society, can be accompanied by neurologic and systemic symptoms, and is characterised by mild or severe recurring headache attacks. The aim of this study is to determine serum apelin-36 level in the patients with migraine with aura and without aura and to compare the obtained data with the data of the healthy control group. The migren study group consisted of 44 women patients, suffering from migraine with (n = 16) and without (n = 28) aura were assessed during the migraine attack, immediately after, and during the headache-free period. The apelin-36 levels of the individuals in the patient and control groups were determined by ELISA method. In all migraine groups with aura (1.86 ± 0.67) and without aura (1.85 ± 0.77), serum apelin-36 levels were significantly higher as compared to the control (0.44 ± 0.07) (p < 0.001). Our findings support the relationship between migraine and the apelin-36 levels.
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