In this preliminary study using Haralick texture parameters based on preoperative clinical FLAIR sequence, the homogeneity parameter could separate IDH mutated LGG from IDH wild type LGG. Combined with tumor volume, these diagnostic properties seem promising.
Implantable
medical device-related infections with biofilms have
become a significant challenge in clinics. Based on the potential
bacteria biofilm dispersing effect of nitric oxide (NO) and the unique
antibacterial activity of antimicrobial peptides (AMP), we synthesized
five peptides and selected the most potent one to conjugate its N-terminal
with a furoxan moiety to offer a hitherto unknown NO-donating antimicrobial
peptide (FOTyr-AMP), which exhibited Staphylococcus
aureus and Escherichia coli biofilm dispersion and eradication, and potent antibacterial activities
in vitro. In an implanted biofilm infection mice model, topical subcutaneous
injection of FOTyr-AMP allowed synergetic eradication
of bacterial biofilms and potent antibacterial activity, superior
to the antibiotic cephalosporin C. Given the low hemolysis effect,
little influence on the blood pressure, and potent in vivo efficacy
of FOTyr-AMP, it is clear that subcutaneous administration
of FOTyr-AMP could be a promising approach for the intervention
of medical device-related biofilm infections with desirable safety.
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