Currently,
one of the main reasons for the ineffectiveness
of tumor
treatment is that the abnormally high tumor interstitial pressure
(TIP) hinders the delivery of drugs to the tumor center and promotes
intratumoral cell survival and metastasis. Herein, we designed a “nanomotor”
by in situ growth of Ag2S nanoparticles on the surface
of ultrathin WS2 to fabricate Z-scheme photocatalytic drug
AWS@M, which could rapidly enter tumors by splitting water in interstitial
liquid to reduce TIP, along with O2 generation. Moreover,
the O2 would be further converted to reactive oxygen species
(ROS), accompanied by increased local temperature of tumors, and the
combination of ROS with thermotherapy could eliminate the deep tumor
cells. Therefore, the “nanomotor’’ could effectively
reduce the TIP levels of cervical cancer and pancreatic cancer (degradation
rates of 40.2% and 36.1%, respectively) under 660 nm laser irradiation,
further enhance intratumor drug delivery, and inhibit tumor growth
(inhibition ratio 95.83% and 87.61%, respectively), and the related
mechanism in vivo was explored. This work achieves efficiently photocatalytic
water-splitting in tumor interstitial fluid to reduce TIP by the nanomotor,
which addresses the bottleneck problem of blocking of intratumor drug
delivery, and provides a general strategy for effectively inhibiting
tumor growth.
he tumor-associated immunosuppression, as a key barrier, prevents the immunotherapy withstanding tumors. Here an ingenious “nanoconverter” was designed to convert immunosuppression to immunoactivation, which was C6-ceramide (C6) modified tumor cytomembrane...
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