In this work, the authors investigated the spring dust storm frequency variations in northern China and its relationship with weather disturbances, cold high, eddy kinetic energy (EKE), as well as the impact of the Arctic Oscillation (AO) on the dust storm frequency variations. It is found that there is a significantly decreasing trend of −26%/10 years in the dust storm frequency variations. In addition, the year-to-year variations are also remarkable, which account for 58.3% of the total variance of the dust storm frequency variations. The synoptic variance of 850 hPa height, EKE, and near-surface cold highs are highly correlated with the dust storm frequency variations. During the last 40 years or so, there have been significant trends in synoptic variance, cold-high frequency, and kinetic energy over northern China and Mongolia, which are −3.2, −4.0, and −5.0%/10 years, respectively. The trends are fairly consistent with long-term variations of dust storm frequency. The AO shows good correlation with the interannual variations of the dust storm frequency. This outof-phase relation is supported by the significantly negative correlations between AO index and eddy growth rate between 850/700 hPa in midlatitude East Asia, implying that AO can modulate weather disturbances and dust storm activities through influencing the atmospheric instability. It is found, however, that the spring AO index shows no evident long-term trend. Land cover changes, global warming, and other climate teleconnections may, at least partly, be responsible for the secular decreasing of dust storm frequency over northern China.

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The aim of this study was to evaluate the effect of the chloroform extract of Terminalia catappa L. leaves (TCCE) on carbon tetrachloride (CCl(4))-induced acute liver damage and D-galactosamine (D-GalN)-induced hepatocyte injury. Moreover, the effects of ursolic acid and asiatic acid, two isolated components of TCCE, on mitochondria and free radicals were investigated to determine the mechanism underlying the action of TCCE on hepatotoxicity. In the acute hepatic damage test, remarkable rises in the activity of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (5.7- and 2.0-fold) induced by CCl(4) were reversed and significant morphological changes were lessened with pre-treatment with 50 and 100 mg kg(-1) TCCE. In the hepatocyte injury experiment, the increases in ALT and AST levels (1.9- and 2.1-fold) in the medium of primary cultured hepatocytes induced by D-GalN were blocked by pre-treatment with 0.05, 0.1, 0.5 g L(-1) TCCE. In addition, Ca(2+)-induced mitochondrial swelling was dose-dependently inhibited by 50-500 microM ursolic acid and asiatic acid. Both ursolic acid and asiatic acid, at concentrations ranging from 50 to 500 microM, showed dose-dependent superoxide anion and hydroxyl radical scavenging activity. It can be concluded that TCCE has hepatoprotective activity and the mechanism is related to protection of liver mitochondria and the scavenging action on free radicals.

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Germline mutations in MSH2, MLH1, E-cadherin and MutY (MYH) genes have been implicated in the occurrence of gastric cancer (GC). Epidemiological investigation was performed by recruiting patients with GC onset during 2002 in Jiangsu province, China. We identified suspected hereditary GC patients based on either the GC family history or GC onset at early ages. We have screened germline variations in 101 suspected hereditary GC patients at the coding sequences of MSH2, MLH1, E-cadherin and MYH genes with polymerase chain reaction-denaturing high-performance liquid chromatography (PCR-DHPLC) analysis and DNA sequencing. The result showed that about 40% of patients carried germline variations, predominantly with missense mutations. Of the variations detected are 2 base pair substitutions, c.53C > T and c.74G > A, which is predicted to generate missense mutations of p.Pro18Leu and p.Gly25Asp, respectively, and occurred at the same allele of MYH gene. The frequency of variant haplotype T/A in patients was higher than that in the control group (p 5 0.021, odds ratio [OR] 5 4.43, 95% confidence interval [95% CI] 5 1.33-14.72). Difference in the frequency of the silent mutation p.Asn751Asn in E-cadherin gene was also found between patients and controls (p 5 0.009, OR 5 2.54, 95% CI 5 1.30-4.95). Moreover, 6 types of variations were detected in MSH2 and MLH1 genes in 14 of 101 patients. Most of them occurred at exon7 of MSH2, frequently c.1168C > T, resulting in mutation of p.Leu390Phe. In summary, germline mutation at MSH2, MLH1, E-cadherin and MYH genes is a frequent event in the familial GC. They may form a genetic basis for the familial GC susceptibility in Chinese population. ' 2006 Wiley-Liss, Inc.

The variation of G>T in the MUC5B promoter (rs35705950) has been associated with idiopathic pulmonary fibrosis (IPF) and familial interstitial pneumonia (FIP) in Caucasians, but no information is available regarding this variant in the Chinese population. We recruited 405 patients with interstitial lung diseases (ILD), including 165 IPF patients and 2043 healthy controls, for genotyping the MUC5B gene in the Chinese population. One hundred three patients with pneumonia and 360 patients with autoimmune diseases (ADs) were recruited as disease controls. Our results indicated that the prevalence of the minor allele (T) of the polymorphism rs35705950 in healthy Chinese subjects was approximately 0.66%, which was lower than that described in the Caucasian population. The frequencies of the T allele were 3.33% and 2.22% in IPF and ILD patients, respectively, and these values were significantly higher than those of healthy controls (P = 0.001, OR = 4.332 for IPF, and P = 0.002, OR = 2.855 for ILD). A stratified analysis showed that this variant in MUC5B associated with the risk for ILD mainly in older male Chinese subjects. No difference was observed between patients with pneumonia, AD patients, and healthy controls.

Disaster damage assessment is an important basis for the objective assessment of the social impacts of disasters and for the planning of recovery and reconstruction. It is also an important research field with regard to disaster mitigation and risk management. Quantitative assessment of physical damage refers to the determination of the physical damage state of the exposed elements in a disaster area, reflecting the aggregate quantities of damages. It plays a key role in the comprehensive damage assessment of major natural hazard-induced disasters. The National Disaster Reduction Center of China has established a technical work flow for the quantitative assessment of disaster physical damage using remote sensing data.