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By the way of isolated vessel perfusion, the direct effect of TFCM on blood vessel contraction was observed and its influence on blood vessel contraction caused by phenylephrine (PE) or potassium chloride, intracellular calcium releasing and extracellular calcium inflowing. TFCM did not directly relax or contract vascular rings, but TFCM could significantly inhibit the contraction of the vascular rings caused by phenylephrine (PE), and potassium chloride (compare with those of control, P>0.05), and the same inhibition to the contraction caused by intracellular calcium releasing and extracellular calcium inflowing (compare with those of control, P<0.05). TFCM could inhibit the contraction of vascular rings caused by phenylephrine and potassium chloride, whose possible mechanism was to inhibit intracellular calcium releasing and extracellular calcium inflowing.