Background:The brain area stimulated during repetitive transcranial magnetic stimulation (rTMS) treatment is important in altered states of consciousness. However, the functional contribution of the M1 region during the treatment of high-frequency rTMS remains unclear.Objective: The aim of this study was to examine the clinical [the Glasgow coma scale (GCS) and the coma recovery scale-revised (CRS-R)] and neurophysiological (EEG reactivity and SSEP) responses in vegetative state (VS) patients following traumatic brain injury (TBI) before and after a protocol of high-frequency rTMS over the M1 region.Methods: Ninety-nine patients in a VS following TBI were recruited so that their clinical and neurophysiological responses could be evaluated in this study. These patients were randomly allocated into three experimental groups: rTMS over the M1 region (test group; n = 33), rTMS over the left dorsolateral prefrontal cortex (DLPFC) (control group; n = 33) and placebo rTMS over the M1 region (placebo group; n = 33). Each rTMS treatment lasted 20 min and was carried out once a day. The duration of this protocol was a month with 20 treatments (5 times per week) occurring with that time. Results:We found that the clinical and neurophysiological responses improved after treatment in the test, control, and placebo groups; the improvement was highest in the test group compared to that in the control and placebo groups. Conclusions:Our results demonstrate an effective method of high-frequency rTMS over the M1 region for consciousness recovery after severe brain injury.
Objective: This study will measure the geometric and pressure centerlines of the foot’s plantar region in healthy Chinese youth to construct a gait norm. Methods: In the present experiment, 203 healthy college students and postgraduates (90 males and 113 females) were recruited as subjects. Their average age was [Formula: see text] years old, average height was [Formula: see text][Formula: see text]cm, and average weight was [Formula: see text][Formula: see text]kg. A double-blind method was used in this experiment. The plantar pressure and gait parameters of time and space among subjects were tested using a gait and balance function-training evaluation system. Data were collected using five pressure-sensor plates, based on the distribution in the geometric and pressure centers of the foot’s plantar area, according to the calculation formula of biomechanics. Results: From 20 selected subjects, the experiment gathered a total of 197 data points from the plantar pressure during walking. The results defined the foot’s centerline of maximum pressure while walking and showed that the pressure and geometric centerlines tended to converge and overlap in normal youth, irrespective of gender. In addition, differences were found between the foot’s centerline of pressure and the geometric and pressure centerlines of the plantar. Conclusion: This study showed that the plantar’s pressure and geometric centerlines can be used as a reference to assess normal gait in Chinese youth.
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