Lung cancer is the most prominent cause of global cancer-related death. The five-year mortality is approximately 80% due to unsatisfied early diagnosis and curative therapeutic strategy. 1,2 Non-small-cell lung cancer (NSCLC) accounts for 85% of the total lung cancers and is pathologically subtyped into adenocarcinoma, squamous cell carcinoma (SCC) and large cell carcinoma (LCC). 3 Owing to the improved understanding of NSCLC tumorigenesis and progression, new biomarker-targeted therapies have advanced the

We have studied the stress-induced martensitic transformation behaviors and the associated elastocaloric effect (eCE) for non-textured polycrystalline all-d-metal Heusler alloys of Ni50Mn32Ti18 and Ni35Co15Mn35Ti15 by a combination of Digital Image Correlation (DIC) and Infrared (IR) thermography techniques. A large but irreversible adiabatic temperature change (ΔTad) of 10.7 K at a strain level of 3.9% is observed for Ni50Mn32Ti18, whereas Ni35Co15Mn35Ti15 exhibits a reversible eCE with ΔTad = 9.0 K at a strain level of 4.6%. At lower strain levels (<2.4%), both specimens exhibit full superelasticity without residual strain. While in a higher strain range (>3.2%), Ni50Mn32Ti18 is plastically deformed with small strain variation in space from the DIC map. In contrast, Ni35Co15Mn35Ti15 can be deformed superelastically accompanied by large strain variation in space, which can be ascribed predominately to the crystalline orientation dependence of both the transformation strain and the Young's modulus from different orientated grains under mechanical loading. The improved reversibility of eCE for Ni35Co15Mn35Ti15 is supposed to be associated with the enhancement of d-d hybridization by the introduction of the element Co.

Background: Adherence to secondary prevention is an indispensable part of the management of patients with coronary artery disease. Finding patient factors affecting their adherence behaviours is important for improving the treatment effect and limiting further disease progression. Aims: To examine the association between health literacy, self-efficacy, disease knowledge and adherence to secondary coronary artery disease prevention in patients in China. Methods: In this cross-sectional study, 598 patients with coronary artery disease were enrolled in two tertiary hospitals in China during a hospitalisation for receiving percutaneous coronary intervention. Patient-reported data were collected on demographics, health literacy, self-efficacy, disease knowledge and adherence to secondary coronary artery disease prevention (medication-taking and heart-healthy lifestyle (exercise, reducing/eliminating alcohol intake and smoking, low salt and fat diet, stress reduction)). Chi-squared tests and regression analyses were performed. Results: The proportions of recalled self-report of adherence to medication-taking and a heart-healthy lifestyle immediately prior to the coronary artery disease hospitalisation were 84.7% and 53.2%, respectively. In logistic regression, health literacy, self-efficacy and disease knowledge was significantly associated with non-adherence to secondary coronary artery disease prevention. Limited health literacy demonstrated a 1.61-fold odds for non-adherence to a heart-healthy lifestyle. Each score increase of self-efficacy and disease knowledge had 0.98-fold odds and 1.05-fold odds of non-adherence to a heart-healthy lifestyle. Conclusions: Adherence to medication-taking was relatively good in Chinese patients prior to coronary artery disease hospitalisation, but adherence to heart-healthy lifestyle behaviours should be improved. Health literacy, self-efficacy and disease knowledge should be taken into account when intervening to improve secondary coronary artery disease prevention.