Copper halide based organic–inorganic hybrid semiconductors exhibit great potential as light‐emitting materials with excellent structural variety and optical tunability. Among them, copper halide hybrid molecular compounds with discrete inorganic modules are particularly interesting due to their high quantum efficiency. However, synthesizing highly efficient blue‐emitting molecular clusters remains challenging. Here, we report a novel and facile strategy for the design and synthesis of highly luminescent copper halide hybrid structures by fabricating coordinated anionic inorganic modules in these ionic species. By using this approach, a family of strongly blue‐emitting copper halide hybrid ionic structures has been prepared with high internal quantum yields up to 98 %. Strong luminescence from the combination of ionic and covalent bonds in these compounds make them ideal candidates as alternative, rare‐earth‐element free light‐emitting materials for possible use in optoelectronic devices.

Copper halide based organic–inorganic hybrid structures exhibit great potential as light‐emitting materials. In their Research Article (e202115225), Wei Liu, Gangfeng Ouyang et al. report a facile strategy for the synthesis of highly luminescent copper halide hybrid structures by fabricating a coordinated anionic inorganic module with a neutral organic ligand molecule. By using this approach, a family of blue‐emitting copper halide hybrid ionic structures have been prepared with high internal quantum yields of up to 98 %.

Copper halide based organic-inorganic hybrid semiconductors exhibit great potential as light-emitting materials with excellent structural variety and optical tunability. Among them, copper halide hybrid molecular compounds with discrete inorganic modules are particularly interesting due to their high quantum efficiency. However, synthesizing highly efficient blue-emitting molecular clusters remains challenging. Here, we report a novel and facile strategy for the design and synthesis of highly luminescent copper halide hybrid structures by fabricating coordinated anionic inorganic modules in these ionic species. By using this approach, a family of strongly blue-emitting copper halide hybrid ionic structures has been prepared with high internal quantum yields up to 98 %. Strong luminescence from the combination of ionic and covalent bonds in these compounds make them ideal candidates as alternative, rare-earth-element free lightemitting materials for possible use in optoelectronic devices.

Abbreviations & Acronyms BC = bladder capacity BP = base pressure BPS = bladder pain syndrome BW-A = bodyweight after instillation BW-B = bodyweight before instillation CMG = cystometry CYP = cyclophosphamide GAG = glycosaminoglycan GAPDH = glyceraldehydes-3-phosphate dehydrogenase HA = hyaluronic acid HAase = hyaluronidase HHAase = high-dose hyaluronidase IC = interstitial cystitis ICAM-1 = intercellular adhesion molecule-1 ICI = intercontraction intervals IL = interleukin LHAase = low-dose hyaluronidase mRNA = messenger ribonucleic acid PP = peak pressure PS = protamine sulfate RNA = ribonucleic acid RT-PCR = reverse transcription polymerase chain reaction RV = residual volume TNF = tumor necrosis factor UPIII = uroplakin III Zo-1 = zonula occludens-1 Objectives: To determine whether a potential rat model of bladder pain syndrome could be developed through long-term intermittent intravesical hyaluronidase. Methods: A total of 64 female Sprague-Dawley rats were divided into a control group, a low-dose hyaluronidase (1 mg/mL) group, a high-dose hyaluronidase (4 mg/mL) group and a hyaluronic acid-treated group. Hyaluronidase was given intravesically three times a week for 1 month. Hyaluronic acid (0.5 mL, 0.8 mg/mL) was introduced intravesically to hyaluronidasetreated rats' bladders. Histological changes, cystometry, nociceptive behaviors, and messenger ribonucleic acid levels of inflammatory factors were evaluated and compared between groups. Results: All hyaluronidase-treated rats showed chronic inflammation and fibrosis, increased and activated mast cells, thinned bladder epithelium with abnormal expressions of uroplakin III and zonula occluden-1, and increased levels of interleukin-6 and intercellular adhesion molecule-1 messenger ribonucleic acid. However, the inflammatory score and levels of interleukin-6 and intercellular adhesion molecule-1 were more significant in the high-dose hyaluronidase group than in the low-dose hyaluronidase group (P < 0.01). Furthermore, hyaluronidase-treated rats showed markedly decreased intercontraction intervals, bladder capacity and increased sensitivity to pain compared with controls (P < 0.01). Hyaluronic acid treatment significantly decreased the inflammatory level, number of mast cells, sensitivity to pain, levels of interleukin-6 and intercellular adhesion molecule-1, and increased intercontraction intervals and bladder capacity (P < 0.01). Conclusions: Long-term intermittent intravesical hyaluronidase could develop a severe chronic cystitis with diffused fibrosis accompanied by altered histology and bladder function. This chronic cystitis rat model can resemble the clinical and histopathological features of human bladder pain syndrome, and might be a potential valuable model for investigation of this troublesome disease.

Pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare and histologically distinctive subtype of nonsmall cell lung cancer (NSCLC). High expression of programmed death ligand 1 (PD-L1) and scarcity of druggable driver mutations raise the potential of immunotherapy for advanced PELEC. However, evidence on the clinical impact of immune-checkpoint inhibitors (ICIs) remained limited and unconvincing. The present study retrospectively enrolled advanced PLELC patients who received ICIs either as up-front or salvage therapy in SYSUCC between March 15, 2017 and March 15, 2022. The comparative efficacy of chemoimmunotherapy vs chemotherapy in the first-line setting and chemoimmunotherapy vs ICIs monotherapy in the ≥2 line setting was investigated. A total of 96 patients were finally enrolled; 49 PLELC patients received immunotherapy plus platinum-based chemotherapy, while 45 patients received platinum-based chemotherapy as first-line treatment. Patientswith chemoimmunotherapy significantly obtain more survival benefits than those receiving chemotherapy (median progression-free survival [PFS]: 15.6 vs 8.6 months, P = .0015). Additionally, patients with chemoimmunotherapy obtained more PFS benefits than those with ICIs monotherapy in the ≥2 line of therapy (median PFS: 21.7 months vs 7.8 months, P = .094). A significant correlation was observed between prognostic nutritional index (PNI) and favorable treatment outcomes in patients receiving first-line chemoimmunotherapy (median PFS: 17.8 months vs 7.6 months, P < .0001). Likewise, patients in the monocyte-to-lymphocyte ratio (MLR)-high group had significantly shorter PFS than the MLR-low group (median PFS: 11.2 months vs not reached, P = .0009). Our study elucidated the superior efficacy of ICIs therapy, especially chemoimmunotherapy in advanced PLELC, which may provide new insight into the role of immunotherapy in advanced PLELC.

Copper(I) halide organic‐inorganic hybrid luminescent materials have many advantages, such as diverse structure, facile synthesis, high luminescent efficiency, tunable optical performance, etc., and show a broad application prospect in energy‐saving lighting, display and other fields. However, compared with commercial rare‐earth‐metal‐based phosphors, the reported hybrids generally suffer from poor stability and low luminescent efficiency, which are the bottleneck problem of their practical application. With the aim of developing high‐performance organic‐inorganic hybrid luminescent materials, a new synthesis strategy has been reported. This strategy can systematically design and synthesis copper(I) halide ionic hybrid structures by combining the covalent bonding and ionic bonding between inorganic and organic components into one structure, and use their synergistic effect to optimizing their properties. This design method is expected to develop high‐performance organic‐inorganic hybrid luminescent materials, promote the in‐depth understanding of this field, and provide new ideas for the optimization of other types of hybrid materials.

A photoluminescent organic−inorganic hybrid coating is synthesized by the incorporation of an emissive Cu 4 I 4 core into a cross-linked coating network through Cu−P coordination bonds. The hybrid coating not only emits strong yellow emission under UV-light irradiation but also exhibits corrosion protection of the metallic surface. Moreover, bactericidal properties are studied that were first reported for Cu 4 I 4 -based hybrid light-emitting materials.

Organisch‐anorganische Hybridstrukturen auf Kupferhalogenidbasis haben ein großes Potenzial als lichtemittierende Materialien. In ihrem Forschungsartikel (e202115225) berichten Wei Liu, Gangfeng Ouyang et al. über eine einfache Strategie für die Synthese von stark lumineszierenden Kupferhalogenid‐Hybridstrukturen durch Herstellung eines koordinierten anionischen anorganischen Moduls mit einem neutralen organischen Ligandenmolekül. Mit diesem Ansatz wurde eine Familie blau leuchtender Kupferhalogenid‐Hybridstrukturen mit hohen internen Quantenausbeuten von bis zu 98 % hergestellt.