To realize nano-ampere current reference generator, a tunable 1.34 nA current reference generator is proposed by applying the reference voltage to a PMOSFET achieving low temperature coefficients (TCs). Unlike the conventional resistors occupying large die area, the area was significantly reduced by using the gate-leakage PMOSFET. Furthermore, the area-efficient reference voltage based on MOSFETs operated at subthreshold rather than the accurate but power- and area-hungry bandgap reference was utilized. To cope with process variations, the reference current can be trimmed by four switches and is easy to be replicated. The proposed current generator was designed and fabricated on the die area of 0.0175 mm^2 using 90 nm CMOS technology. The measured TC of the 308 mV voltage reference is 124 ppm/°C and the measured TC of the 1.34 nA current reference is 394 ppm/°C from 0°C to 120°C at a supply voltage of 0.75V.

We report a case of subglottic narrowing caused by an extranodal deposit of sinus histiocytosis in a 55-year-old man. To the best of our knowledge, no previous reports have described diagnosis using sonographic-guided fine-needle aspiration cytology for Rosai-Dorfman disease of the subglottis. This patient was diagnosed by sonographic-guided fine-needle aspiration biopsy, which revealed lymphocytes, plasma cells, and many foamy, multinuclear histiocytes with preserved lymphocytes in their cytoplasm (emperipolesis). The patient underwent an incisional biopsy of the tumor and received postoperative steroids and low-dose chemotherapy. The subglottic tumor was markedly regressed 6 months later.

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A concise approach to the total syntheses of racemic paniculidines B and C is described. The route features a combined Tamaru allylation/olefin cross-metathesis sequence for the regiocontrolled synthesis of prenylindole intermediates. In addition, we report a transformation of the prenylated indole into 2-methylcarbazole catalyzed by sulfonic acid-functionalized silica gel.