Nanomaterials
(NMs) inevitably adsorb proteins in blood and form
“protein corona” upon intravenous administration as
drug carriers, potentially changing the biological properties and
intended functions. Inspired by anti-adhesion properties of natural
proteins, herein, we employed the one-bead one-compound (OBOC) combinatorial
peptide library method to screen anti-adhesion peptides (AAPs) against
proteins. The library beads displaying random peptides were screened
with three fluorescent-labeled plasma proteins. The nonfluorescence
beads, presumed to have anti-adhesion property against the proteins,
were isolated for sequence determination. These identified AAPs were
coated on gold nanorods (GNRs), enabling significant extension of
the blood circulating half-life of these GNRs in mice to 37.8 h, much
longer than that (26.6 h) of PEG-coated GNRs. In addition, such AAP
coating was found to alter the biodistribution profile of GNRs in
mice. The bioinspired screening strategy and resulting peptides show
great potential for enhancing the delivery efficiency and targeting
ability of NMs.
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