Incorporationof 2-deoxy-o-galactose into the oligosaccharide moieties of different gangliosides of rat liver was examined. After intraperitoneal administration of 2-deoxy-n-galactose it was shown by GLC/MS analysis that this hexose analogue is metabolized and incorporated into all the ganghosides investigated. and predommantly mto G,, and G,,. In both of these gangliosides. 25-55% of the galactose residues were substituted by 2-deoxy-n-galactose.The epimer, 2-deoxy-n-glucose, was not detectable.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.