Controlling lung cancer cell migration and invasion via epithelial-to-mesenchymal transition (EMT) through the regulation of epidermal growth factor receptor (EGFR) signaling pathway has been demonstrated. Searching biological active phytochemicals to repress EGFR-regulated EMT might prevent lung cancer progression. Propolis has been used as folk medicine in many countries and possesses anti-inflammatory, antioxidant, and anticancer activities. In this study, the antimigration and anti-invasion activities of propolin C, a c-prenylflavanone from Taiwanese propolis, were investigated on EGFR-regulated EMT signaling pathway. Cell migration and invasion activities were dose-dependently suppressed by noncytotoxic concentration of propolin C. Downregulations of vimentin and snail as well as upregulation of E-cadherin expressions were through the inhibition of EGFR-mediated phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) and extracellular signal-regulated kinase (ERK) signaling pathway in propolin C-treated cells. In addition, EGF-induced migration and invasion were suppressed by propolin C-treated A549 lung cancer cells. No significant differences in E-cadherin expression were observed in EGF-stimulated cells. Interestingly, EGF-induced expressions of vimentin, snail, and slug were suppressed through the inhibition of PI3K/Akt and ERK signaling pathway in propolin C-treated cells. Inhibition of cell migration and invasion by propolin C was through the inhibition of EGF/EGFR-mediated signaling pathway, followed by EMT suppression in lung cancer.
Figure 1. Applications of Morphlour. Dehydration-based examples through baking, including (a) Self-wrapping cannoli, (b) Selfwrapping tacos, and (c) Self-folding multi-flavored cookies. Hydration-based examples through boiling, including (d) Selfassembling noodles for accessibility, (e) Flat-pack hiking food, and (f) Shape customization for special events -morphing heart shape.
The strongest intermolecular interactions between DBS molecules in the DBS/PEG systems led to the more regular structure compared with the DMDBS/PEG and TBPMN/PEG systems.
Wearables have emerged as an increasingly promising interactive platform, imbuing the human body with alwaysavailable computational capabilities. This unlocks a wide range of applications, including discreet information access, health monitoring, fitness, and fashion. However, unlike previous platforms, wearable electronics require structural conformity, must be comfortable for the wearer, and should be soft, elastic, and aesthetically appealing. We envision a future where electronics can be temporarily attached to the body (like bandages or party masks), but in functional and aesthetically pleasing ways. Towards this vision, we introduce ElectroDermis, a fabrication approach that simplifies the creation of highly-functional and stretchable wearable electronics that are conformal and fully untethered by discretizing rigid circuit boards into individual components. These individual components are wired together using stretchable electrical wiring and assembled on a spandex blend fabric, to provide high functionality in a robust formfactor that is reusable. We describe our system in detailincluding our fabrication parameters and its operational limits-which we hope researchers and practitioners can leverage. We describe a series of example applications that illustrate the feasibility and utility of our system. Overall, we believe ElectroDermis offers a complementary approach to wearable electronics-one that places value on the notion of impermanence (i.e., the opposite of tattoos and implants), better conforming to the dynamic nature of the human body. CCS Concepts • Human-centered computing~ Ubiquitous and mobile computing systems and tools.
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