A series of open-chain tetrapyrroles, each carrying one or more 13 C-labels in its three ring-bridging methine groups, were synthesized. These compounds - [5-, [10-, and [15-13 C]-phycocyanobilins (PCB), [10-13 C]-phytochromobilin, and [10,15-13 C 2 ]-PCB -were each obtained by a convergent route, starting with the four pyrrole building blocks, with the initial formation of the left and the right halves of the tetrapyrrole separately, followed by a final condensation of the two dipyrrole units to yield the target bilin compound. The
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