The simultaneous delivery of NO and H2S from prepared self-assembled polymeric nanoparticles shows advantages of a controlled release concentration and improved angiogenic properties in vitro and ex vivo by a synergistic effect.
Extracellular vesicles (EVs) have been found to be effective therapeutic drug delivery vehicles in a wide range of human diseases, including cancer and neurodegenerative diseases. Proinflammatory (M1) macrophages can modulate the suppressive immune environment of tumor tissues to be more inflammatory and have been considered as candidates for cancer immunotherapy. Furthermore, macrophage-derived exosome-mimetic nanovesicles (MNVs) could effectively induce antitumor response and enhance the efficacy of immune checkpoint inhibitors in a recent paper. However, multiple studies indicate that EVs were rapidly cleared by the reticuloendothelial system, and therefore, their tumor targeting efficiencies were limited. Herein, we developed a simple surface modification method of MNVs using polyethylene glycol (PEG) to enhance the in vivo tumor targeting efficiency. PEG-MNVs had 7-fold higher blood circulation than bare MNVs in the animal tumor model. Also, MNVs had a 25-fold higher protein amount than exosomes. Overall, the nanovesicle preparation strategies presented in this study may expedite the clinical translation of EV-based therapeutics in various diseases.
This review comprehensively reviewed floating offshore wind power generation technology, which is being newly developed as a mid- to long-term plan for wind energy. From the perspective of investment per megawatt (MW), offshore wind power is still about 50 percent more expensive than land wind power. Nevertheless, many advanced countries began to investigate the data because they wondered why they were immersed in development and investment, and why offshore wind facilities installed on the beach and floating offshore wind installed in the middle of the sea, unlike the land wind we knew. We looked at the basic principles of offshore wind power generation and the technologies used in facilities, and looked at the advantages and disadvantages of offshore wind power generation compared to land wind power generation, and what differences between fixed offshore wind farms and floating offshore wind farms. It is investigated whether it is a realistic plan to verify residents’ opposition to the installation of offshore wind power facilities, the possibility of commercialization such as high operational management costs, and the feasibility of installing facilities for renewable energy 3020 as mid- to long-term goals. In addition, it compares foreign cases with offshore wind power development complexes in Korea, marine wind power generation complexes in operation, and high wind power in Scotland, the first floating offshore wind power in Ulsan, Korea, to overcome difficulties in installing facilities and suggest directions for domestic offshore wind power development. In addition, in Korea, where there are not many countries suitable for wind power generation unlike overseas, it was decided to investigate whether floating offshore wind power could be the answer as planned. The reason why the government is pushing for investment in renewable energy such as solar power and wind power is because energy sources from the sun are eco-friendly. However, the U.S. and Europe, which started the wind power project early, are having difficulty in handling the wings of wind power generators. The energy source looked at the contradictions caused by environmental pollution in the treatment of waste, although it was environmentally friendly, and investigated how waste was treated and utilized overseas. Compared to other countries that entered the offshore wind power business earlier, domestic power generation projects are in their infancy and should focus on developing technology and co-prosperity with neighboring residents rather than on excessive expansion.
PURPOSE: This study was conducted in chronic hemiplegic patients to examine the effect of the training of the ipsilateral arm that is identical to the model performing movements and the training of the contralateral arm on the function of the arm. METHODS: The subjects were participated total 2 patients(the subject 1 with left hemiplegia and the subject 2 with right hemiplegia). The study was conducted for 4 weeks. The action observation training were repeated 10 times in 10 days during intervention period. The evaluation of the arm function such as BBT, MFT and MAL in the each subject were examined 5 times in the baseline period, 10 times during the intervention period and 5 times during the baseline regression period. RESULTS: The results of the evaluation in each subject were presented as mean values and video graphs. The arm function of the 2 subjects were improved during the
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