This study examined the postoperative pain management practices among registered nurses in an urban hospital in Vietnam. Data of 90 nurses about postoperative pain management practices and pain management at the department were collected. Results indicated that 83.3% of nurses reported that they regularly assessed the degree of pain for postoperative patients. Only 32.2% used assessment tools such as the numeric rating scale to measure pain. Experience in pain management and having guidelines in the department were associated with a higher score in pain management practice. Findings suggested that facilitating the use of pain instruments and developing pain management guidelines should be prioritized.

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The potential targeting of xanthine oxidase (XO) for the treatment of gout has been explored through animal and human experiments. To identify potential XO inhibitors, a virtual screening method was utilized to examine fatty acids from Hedyotis pilulifera. Molecular docking results demonstrated that all possible configurations of the fatty acid 9,12,13-trihydroxyoctadeca-10 E,15 Z-dienoic acid exhibited a strong binding affinity to XO. In vitro experiment also showed that this compound inhibited XO activity compared to the control compound. Molecular dynamic simulation was used to further investigate the interaction between the ligand and protein. Additionally, ADMET studies revealed that this compound has highly favorable drug-like properties and pharmacokinetics.