In vivo dosimetry allows for a specified total whole-body radiation dose to be delivered accurately. This schedule of intensification of (131)I-mIBG therapy by dose escalation and radiosensitization with topotecan with a haemopoietic autograft is safe and practicable. This approach should now be tested for efficacy in a phase II clinical trial.

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The skin permeability (Kp) defines the rate of a chemical penetrating across the stratum corneum. This value is widely used to quantitatively describe the transport of molecules in the outermost layer of epidermal skin and indicate the significance of skin absorption. This study defined a Kp quantitative structure-activity relationship (QSAR) based on 106 chemical substances of Kp measured using human skin and interpreted the molecular interactions underlying transport behavior of small molecules in the stratum corneum. The Kp QSAR developed in this study identified four molecular descriptors that described the molecular cyclicity in the molecule reflecting local geometrical environments, topological distances between pairs of oxygen and chlorine atoms, lipophilicity, and similarity to antineoplastics in molecular properties. This Kp QSAR considered the octanol-water partition coefficient to be a direct influence on transdermal movement of molecules. Moreover, the Kp QSAR identified a sub-domain of molecular properties initially defined to describe the antineoplastic resemblance of a compound as a significant factor in affecting transdermal permeation of solutes. This finding suggests that the influence of molecular size on the chemical’s skin-permeating capability should be interpreted with other relevant physicochemical properties rather than being represented by molecular weight alone.

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Chronic osteomyelitis with proliferative periostitis (Garré's sclerosing osteomyelitis) is a distinctive type of chronic osteomyelitis that mainly affects children and young adults. Here we report on a 9-year-old girl in whom the condition arose following a pulpoperiapical infection in a mandibular right primary secondary molar. Clinically, it manifested as a bony, hard, mildly tender swelling. Radiography revealed a pathognomonic patchy thickening with radiolucency and radiopacity. The dental inflammation and infection were eliminated and conservative therapy followed. The patient was otherwise asymptomatic. Remission of the disease process and reappearance of a normal-looking mandible was observed with computed tomography imaging, three-dimensional reconstruction and a bone scan at a 10-month follow up visit.