The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.202204512. approved as a new drug. [2] Only around 50 drugs are approved by the FDA in a year and there is a high demand to continue and improve this trend. Especially thinking about orphan drugs, it is important to reduce the time and cost consumption in all stages of the drug development process. [1] In order to accelerate development of novel functional materials, chemicals, or drug candidates, high-throughput and miniaturized synthetic methods are important. [3] Integration of such miniaturized synthesis with biological high-throughput screenings (chemBIOS approach) [4][5][6] is essential to get rid of the technological and conceptual gap between these two steps in drug discovery. [7] This is necessary to accelerate the hit detection and optimization in the early stage of drug development, which can usually take 6 years or more. [8] Until now, this has been challenging partly due to the necessity of purification of synthesized compounds in highly miniaturized and in parallel high-throughput way. [9] Moreover, the purification methods have to be compatible with the same platform to be used for both synthesis and biological screenings. For this reason, the overwhelming majority of miniaturized highthroughput synthesis methods is still done using solid-phase synthesis (SPS), thus, allowing simple removal of side products and added reagents by washing. [10]
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