Established decarboxylative Minisci reactions are limited to aliphatic carboxylic acids, as their analogs, silanecarboxylic acids, have been rarely investigated. Herein, we present a new decarboxylative minisci-type reaction of N-heteroarenes with...
Established carboxylic acids to nitriles conversion methods
suffer
from expensive catalysts, tedious steps, high temperatures (>200
°C),
high pressure, or a narrow substrate range. Herein, we demonstrate
a concise and efficient access to diverse nitrile compounds from ubiquitous
carboxylic acids with electron-deficient N-cyano-N-aryl–arylsulfonamide (NCAS) in moderate to excellent
yields. This strategy is promoted by an inexpensive iron catalyst
and is generally compatible with primary, secondary, tertiary, and
aryl carboxylic acids, as well as a variety of functional groups.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.