High hydrogen content and excellent stability at room temperature promote hydrazine borane (HB, N2H4BH3) as a promising chemical hydrogen storage material. However, the development of high efficient and selective catalysts...
A new
codelivery system combining prodrug strategy, siRNA/BAplatin
@CRGDK NPs, to overcome cisplatin (CDDP) resistance in human
breast cancer was designed and researched. Negatively charged siRNA
was deposited onto the surface of tumor-targeting peptide-functionalized
BAplatin@CRGDK NPs. SiRNA/BAplatin@CRGDK NPs could facilitate cellular
uptake of BAplatin and increase the cell proliferation suppression
effect of Pt against MDA-MB-231/DDP cells. The tumor-to-kidney uptake
ratio of the siRNA/BAplatin@CRGDK NPs in MB-231/DDP tumors is 2.4-fold
higher than that of cisplatin in MB-231/DDP tumors, thus giving rise
to more significant antitumor efficacy. It demonstrated that the siRNA/BAplatin@CRGDK
NPs is a potential, safe, and efficient therapeutic agent for cancer
therapy.
The treatment, disposal and management of municipal solid waste strongly depend on the composition and characteristics of municipal solid waste. The Physical composition of MSW and its influencing factors were investigated and analyzed in the residential of Beijing area. The result showed that the composition of MSW in four seasons was similar, and the kitchen was the main composition of MSW, accounting for 69-74% of the total amount of MSW. The average age of families, educational backgrounds, family income and building area have a great influence on the physical proportion of MSW. As the average age of the family increases, the proportion of other wastes was gradually reduced, the proportion of the harmful waste was increased. With the increase of educational backgrounds and family income, the content of kitchen waste decreased, while the content of recyclable waste increased obviously. The 50 square meters was used as a dividing point for the residential area of the family, the kitchen waste decreased at first and then increased, while the proportion of disposable packaging and other waste increases at first and then decreases with the increase of building area.
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