Prophylactic effects upon imunnosuppressed mice lethally infected by Candida albicans were examined in fractions prepared from a constituent herb of Juzen-taiho-to (TJ-48, Si-Quan-Da-Bu-Tang), rhizomes of Atractylodes lancea DC. The oral administration of water extract obtained from a residue after MeOH extraction of rhizomes significantly prolonged the survival period of the infected mice at a dose of 140 mg/kg/day compared with control mice, while the MeOH extract did not. In the crude polysaccharide fraction (F-2) obtained by EtOH precipitation of the water extract, a significant life-prolonging effect was observed by the administration of 70 mg/kg/day. F-2 was further fractionated, and the resulting strongly acidic polysaccharide fraction, F-2-2, had a protective effect at a dose of 17.5 mg/kg/day. This fraction mainly consisted of acidic pectic polysaccharides containing about 80% galacturonic acid. The protective activity of F-2-2 was lost by periodate oxidation, but not by protease digestion, suggesting that the polysaccharide component of F-2-2 plays a major role in the protective activity against Candida-infected mice.
A 42-year-old woman with bulimia nervosa presented to the emergency room with increasing weakness and vomiting. The physical examination was remarkable for her weight of 26.1 kg, distended but non-tender abdomen with decreased bowel sounds. Laboratory tests revealed serum sodium of 124 mmol/L, potassium of 1.6 mmol/L, magnesium of 1.4 mmol/L and a leucocyte count of 5.5×10 9 /L. A computed tomography (CT) scan of the abdomen showed marked gas in the portal system, gastric wall and intestinal lumen (Picture A and B). The presence of hepatic portal gas in abdominal radiographs was once thought to be an ominous sign and considered an indication for an emergency laparotomy. The development of CT has created more opportunities to visualize such cases and conservative management is increasingly recognized as being appropriate in many instances especially when signs of bowel ischemia are absent (1). The present patient was transferred to a tertiary care center with a psychiatry unit, treated reportedly conservatively and subsequently discharged 10 days later.The authors state that they have no Conflict of Interest (COI).
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