To prepare powdered medicines without bitter taste, film coating is required to cover the surface of core particles. In this study, effect of formulation and operating conditions of agitation fluidized bed on the core particle properties was investigated. In order to prevent breakage of the core particles during coating process, which sometimes causes variation of drug dissolution rate, addition of maltose syrup powder during the formulation process of the core particles was investigated. Also, a method for friability test in which the core particles were subjected to strong impact was proposed to evaluate strength of the core particles. The friability of the core particles determined by this test method correlated well with the actual friability of the particles during the coating process. Based on this result, we confirmed this novel friability test method could predict the core particle endurance during the coating process.
The organic sediment moves with water flowing in estuary. It is carried to the river with flood tide, and settles on the riverbed at a tidal flat. If the purification ability of the organic sediment is small, the sludging of the tidal flat is accelerated. The organic sediment settled there causes the environment deterioration and loss of waterside scene value. The environmental quality improvement technology using waste recycling products is proposed. The large pore drain is embedded in the consolidated sediment. It can cause the water movement in the drain with the ebb and flood tide, and the water movement raises living thing habitation environment by supplying oxygen into consolidated sediment.
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