Vogt-Koyanagi-Harada's (VKH) disease is reported to be closely associated with the HLA class II antigen, HLA-DR4. Serologically defined DR4 is further divided into 11 alleles by molecular HLA genotyping. However, no study of HLA-DNA typing of VKH patients has been reported. To The HLA class II region in the major histocompability complex (MHC) on human chromosome 6 encodes the heterodimeric (a and ,B chains) glycoproteins expressed on the surface of antigen-presenting cells in the immune system. The T cell receptor interacts with a complex formed by the antigenic peptide fragment bound by the HLA molecule on the antigen-presenting cells. On the basis of x ray crystallographic analysis of the HLA class I antigen, HLA-A2, the outermost domains of each class II chain are predicted to fold together to form a groove and cleft, and so appear to function by trapping the antigenic peptide fragment into a groove for the presentation to antigenic-restricted T cells in the initiation of immune response. The genetic polymorphism of class II molecules is known to be clustered into the discrete regions of the 13

No abstract

No abstract

No abstract