Background:We investigated the extent of growth of microorganisms with simultaneous administration of lipid emulsions with infusions for Total Parenteral Nutrition (TPN), assuming that the lipid emulsions contaminated with microorganisms are stagnant in a closed-type infusion device. We also investigated if bacterial growth can be prevented in the infusion device by flushing the inside of the infusion device with saline solution after the administration of lipid emulsion from the side tube in vitro setting. Methods: We made a preparation by adding Escherichia coli to the lipid emulsion and started the infusion simultaneously with the infusion solution for TPN and lipid emulsion with the piggyback method. Immediately after the completion of lipid emulsion infusion, we conducted flushing with saline solution. The volume of saline solution was none, 5, 10, or 20 mL at a flow rate of 1 mL/s. Infusion solution that was stagnant in the infusion device was collected immediately before completing the lipid emulsion infusion and 20 h after flushing, i.e., 24 h after starting the infusion for TPN, and the number of viable bacteria was determined. Results: The number of viable E. coli increased in the infusion device of all three species used in this experiment 24 h after starting the lipid emulsion infusion without flushing. We found that bacterial growth could be prevented through flushing with saline solution after the completion of lipid emulsion infusion and flushing out the stagnant infusion solution in the closed-type infusion device. Conclusions: We found that if E. coli was present in the closed-type infusion device, it would multiply. We also found that the number of viable bacteria varied according to the variety and internal structure of the closed-type infusion device as well as the liquid volume used for flushing, although flushing can prevent the growth of microorganisms. Proper management and manipulation of infusion is required to prevent infection.
Several hospitalized patients have a history of medication use; consequently, there are numerous reports on the importance of pharmacists managing their own medications. Conversely, there is a lack of information about the status of patients medication adherence. Therefore, we collected data on medicines brought to hospital by inpatients and investigated their medication compliance status. The medication compliance status of patients visiting the Kokuho Chuo Hospital from April 2017 to March 2018 was investigated using the identi cation sheets of medicines brought by these patients and patients medical records. The number of differentiations of medicines brought to the hospital by inpatients was 1,080, and the details of 889 medicines were used in this study. The average number of medicines brought per patient was 5.6 3.5, with elderly patients bringing more medicines and exhibiting a low medication compliance. Compliance with antibiotics, chemotherapeutics, and oncology drugs was good, whereas that of vitamins, peripheral nervous system agents, and drugs for treating sensory organ issues was poor. The cost of medication per patient among nonadherent patients was approximately 3,836 11,078 yen, amounting to a total cost of 3,409,914 yen. The medication compliance status inferred from this study was worse among elderly patients as well as for medicines used to treat chronic diseases. Pharmacists can provide appropriate drug treatments and contribute toward reducing healthcare costs by increasing awareness regarding the family pharmacist system and improving cooperation between community pharmacies and hospitals to improve polypharmacy and medication adherence.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.