BACKGROUND: Flaxseeds are miraculous seeds because of their richness in omega-3, fibers and other healthy compounds, they can be used as a natural remedy for several diseases. OBJECTIVE: This study was carried out to determine the feasibility of supplementing flaxseed powder to yogurt at 3% to benefit from its functional effects such as its richness in proteins, dietary fiber, polysaccharides, polyphenolic compounds and essential fatty acids for health. METHODS: Two types of milk powder were used for the manufacture of yogurt: skimmed milk powder at 15% (w/v) and whole milk powder at 13.7% (w/v). Physicochemical (pH and titratable acidity), microbial (Streptococcus thermophilus and Lactobacillus bulgaricus) and sensory (texture, odour, taste and color) properties of this supplementation were evaluated during the fermentation time and storage at 4 • C. RESULTS: The addition of ground linseed (GFS) decreased the pH values and increased the titratable acidity values during fermentation and refrigerated storage, especially in the case of yogurt manufactured using whole milk powder, where the average pH of samples decreased from 4.37 to 4.20 after 28 days storage while the average titratable acidity increased from 78 to 105 • D. Sensory evaluation revealed that supplemented yogurt had better sensory texture, taste and odour scores than the control sample. Supplementation of GFS significantly increased the average values of lactic acid bacteria CFU counts but at values not exceeding 1.25 × 10 8 CFU/ml for S. thermophilus and 0.85 × 10 7 CFU/ml for Lactobacilllus bulgaricus indicating the possibility of prolonging the shelf life of yogurt.
IntroductionAcute ischaemic stroke (AIS) has been reported as a relatively infrequent complication of Covid-19. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the commonest inherited stroke disorder. Our aim was to determine the clinical and radio- logical features of Covid-19 associated AIS in patients with CADASIL.MethodsWe performed a systematic review of publications of patients with Covid-19 and CADASIL and included one unpublished case from two such presentations to our center.ResultsWe identified a total of 6 cases; average age 46 years, all female. Mean time from Covid-19 to AIS was 9.8 days, with no severe infection. Imaging demonstrated multiple infarcts in 66%, mean number of DWI lesions 9.6, 83% sustained infarcts located in the internal borderzones. An initial diagnosis of neuro- inflammation was revised in 50% following genetics, with 83% unaware of the CADASIL diagnosis.ConclusionsThis systematic review describes the pattern of COVID-19 associated AIS in CADASIL. Such multiple infarcts, primarily affecting the internal borderzones, have been described in patients with Covid-19 without CADASIL. We discuss possible pathophysiological mechanisms, which may be extrapolated to patients with cerebral small vessel disease, including endothelial injury causing microvascular thrombosis and hypoperfusion due to cerebral blood flow dysautoregulation.
This research aims to evaluate the biological activities and physicochemical characterization of the Algerian prickly pear and two varieties of dates (Mech-Degla and Frezza). The phenolic content of these fruits was determined by the Folin-Ciocalteu method. Then, antioxidant activities were studied using two different methods. The antimicrobial activities of the fruit were tested against four bacterial strains and two fungi and then compared to commercial antibiotics. Mech-Degla extract showed a strong antibacterial and antifungal inhibitory effect evaluated against S. aureus, Streptococcus spp, E. coli, P. aeruginosa, G. capitatum, and Candida spp. While Frezza date extract and prickly pear showed a weak effect against some bacterial strains, they had no inhibitory effect on fungi. The antimicrobial activity of Mech-Degla is superior to amikacin, ampicillin, and gentamicin. The Frezza variety had the highest antioxidant capacity, followed by Mech-Degla and the low iron reduction capacity is related to prickly pears. The tested fruits had high levels of polyphenols and flavonoids. This study confirms those species' antioxidant activity and antimicrobial properties and the critical effect of natural antibiotics compared to synthetic ones.
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