View this article online at wileyonlinelibrary.com.The present review covers the methods developed for the synthesis of different pyrano[3,2-c]quinolinones as well as the chemical reactivity of these compounds towards various types of chemical reactions.

Uma variedade de sistemas heterocíclicos contendo o sistema 1-etilquinolin-2(1H)-ona, foi preparada a partir da reação de 3-(nitroacetil)-1-etil-4-hidroxiquinolin-2(1H)-ona com alguns reagentes eletrofílicos e nucleofílicos. Além da sua ciclização para 5-etil-2-(hidroxiimino)-2,3,4,5-tetrahydrofuro[3,2-c]quinolina-3,4-diona, o composto 3-(nitroacetil)-1-etil-4-hidroxiquinolina-2(1H)-ona foi bromado, clorado, formilado, acetilado, e condensado com cromona-3-carbonitrila e 2-amino-3-formilcromona. Alguns novos pirazolo [4,3-c]

2-Methylchromones, although scarce in nature, constitute a group of oxygen heterocyclic compounds which have shown significant biological activities. Their transformations into other biologically active compounds have been exploited. This review describes the work on the synthesis and reactions of 2-methylchromones as well as their biological evaluation.

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