Background: Migraine is fairly common condition affecting about 15% of the population globally and In GBD 2015, it absolutely was ranked as third highest reason for disability worldwide in both males and females under the age of fty years. Thus it is absolutely necessary and interesting to study the effectiveness of homoeopathic anti miasmatic remedies in patients with migraine. Methods: 30 cases of migraine were included in this non randomized clinical study out of 40 registered cases and the data collected during the study was analyzed with paired t test. The study was conducted for period of 18 months. Result: The study showed that the prevalence of migraine was more amongst females (83.33%) compared to male (16.66%). Moreover the age group 15-20 year age group ( 23.33%) followed by 25-30 years and 40-45 years (20%). During the study it was found that Natrum Muriaticum was indicated in moat of the cases ( 13.33%), followed by pulsetilla (10%) followed by lachesis, silicea and belladonna (6.66% each). The most common miasm was found to be sycotic miasm ( 53.33%) followed by psora miasm ( 30%) and syphilitic miasm ( 13.33%). Conclusion: After the study of 30 patients it was found that administration of anti miasmatic medicines in the patients with migraine showed changes in the frequency of episode of headache (Mean difference -2.167, SD of difference 0.7915, p value <0.001), intensity of pain (Mean difference -1.700, SD of difference 1.179, p value <0.001) and changes in quality of life score, MIDAS scores (Mean difference -2.167, SD of difference 0.7915, p value <0.001) which were statistically signicant.
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