Engineering of craniofacial tissues would have a profound impact on various treatment strategies in dentistry. The role of mesenchymal stem cells in the formation of all craniofacial and dental structures has been well demonstrated. Stem cells from various craniofacial structures like dental epithelium, dental follicle, apical papilla, exfoliated deciduous teeth, periodontal ligament and dental pulp are readily accessible and have immense potential in craniofacial research for regenerative and tissue engineering applications. Various signalling molecules that pattern the morphogenesis of craniofacial tissues have been explored. This review article epitomises how dentistry should evolve and highlights the need for close partnerships between basic and clinical scientists.
Aim The aim of the study is to evaluate the prognostic value of b2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC). Materials and Methods The study included 60 patients (15 oral SCC, 15 leukoplakia, 15 individuals exposed to various carcinogens and without oral cancerous or precancerous lesions, 15 healthy individuals). The levels of b2-m were estimated using chemi-luminescent immunometric assay on Immulite fully automated machine. Statistical analysis of the data was done using Tuckey's test, ANOVA and independent sample t test. Results Results showed that b2-m was increased in individuals exposed to carcinogens without precancerous and cancerous lesion. Conclusion Serum b2-m can be used as a better indicator and can give an early indication of malignant change and therefore malignancy can be detected at an early and treatable stage.
The role of ketamine in low doses as an analgesic and anti-inflammatory is evident in our study. The combination of a local anesthetic and sub-anesthetic doses of ketamine injected for surgical removal of impacted third molars provides good local anesthesia while alleviating post-operative sequelae for the patient by providing a degree of post-operative analgesia with less swelling.
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