The synthesis of tri-substituted pyrazoles was achieved via direct N-heterocyclization of hydrazines with metal-acetylacetonate and -dibenzylideneacetonate without using any base or additives under microwave irradiation in a single step.
An enantio‐ and diastereoselective sp3‐sp3 coupling of acyclic/cyclic ketones with dihydrodibenzo‐oxazepines has been developed by merging visible light photo‐redox‐ or electro‐catalysis with organocatalysis. This approach parallelly utilizes Eosin Y or graphite electrodes for the co‐catalyst‐free oxidative conversion of dihydrodibenzo‐oxazepines to oxazepines, followed by L‐Proline catalyzed direct Mannich‐type reaction with ketones. A series of enantioenriched dihydrodibenzo‐oxazepines have been prepared in high yields and enantioselectivity. This method shows substantial advantages over the existing protocols by using potentially safer starting materials and cheap commercially available catalysts.
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