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Cerebral white matter lesions (WML) are major risk factors for bipolar disorder (BD). However, studies on the association between cerebral WML volume and BD risk are limited. This study aimed to investigate the relationship between cerebral WML volume and BD incidence. This is a secondary retrospective analysis of patients (N = 146, 72 males, 74 females, mean age = 41.77 years) who have previously undergone magnetic resonance imaging examinations. Information was obtained from the Dryad database. Univariate analysis, piecewise linear regression model, and multivariable logistic regression model were used for statistical analysis. A non-linear relationship was recognized between the cerebral WML volume and BD incidence, in which the inflection point of the WML volume was 6,200 mm3. The effect sizes and confidence intervals on the left and right sides of the emphasis point were 1.0009 (1.0003, 1.0015) and 0.9988 (0.9974, 1.0003), respectively. Subgroup analysis (WML volume < 6,200 mm3) showed that the cerebral WML volume (for 0.1 mm3 increase) was positively related to the BD incidence (OR = 1.11, 95% confidence interval [CI] (1.03, 1.21)). Here we show that the cerebral WML volume is positively and non-linearly correlated to the BD risk. Volumetric analysis of WML provide a better understanding of the association between WML and the BD risk, and thereby the pathophysiological mechanisms of BD.Graphical abstractA non-linear relationship between the volume of cerebral white matter lesions (WML) and bipolar disorder (BD) incidence is shown. The cerebral WML volume is positively and non-linearly correlated to the BD risk. The correlation is stronger when the cerebral WML volume was <6,200 mm3.Graphical AbstractA non-linear relationship between the volume of cerebral white matter lesions and bipolar disorder incidence is shown after adjusting for age; sex; lithium, atypical antipsychotic, antiepileptic, and antidepressant drug use; BMI; migraine; smoking; hypertension; diabetes mellitus; substance and alcohol dependency; and anxiety disorder.

As the main body of moral education, counselors are the backbone of College Students' Ideological and Political Education. Counselor work plays a key role. It is very important to improve the ideological and political quality of college students, to promote the reform and development of higher education, to maintain the stability of school and society and to promote the all-round development of college students. At present, as the first line of moral education workers in colleges and universities, counselors need to shift from a single experience to complex research, in order to meet the needs of College Students' Ideological and Political Education in the new era. At first, this paper is based on the analysis of the present situation and analyzes the problems existing in the scientific research ability of college counselors from four aspects: the cognition of scientific research, the consciousness of scientific research, the spirit of scientific research, the relevant knowledge base and the scientific research environment. At last, the study puts forward the concrete countermeasures from four aspects: system guarantee, platform support, environmental pull and initiative promotion.

In recent years, the frequency of crisis events has increase trend; the risk of events brought a serious impact on the University campus. It not only disturbs the harmony and stability of the school, but also does harm to the healthy growth of College Students. Therefore, the scientific response to the crisis is an important issue faced by colleges and universities. College counselors are responsible for a student daily management, so they should respond to crisis. The study of correct positioning of the role of college counselors in university crisis events and actively enhancing the ability to respond is of great significance. In this study, we can get a conclusion about the current counselors' understanding and the ability to prepare for the crisis events On the premise of the theory, the paper puts forward some countermeasures and suggestions to improve the ability of coping with crisis events.