In animal husbandry, traditional Chinese medicine (TCM) as a reasonable alternative to antibiotics has attracted more and more concerns to reduce microbial resistance. This study was aimed to investigate the effects of dietary supplementation with TCM prescriptions on serum parameters and thymus inflammation responses in finishing pigs. Thirty finishing pigs were randomly divided into three groups, which included the Con group (basal diet), the TCM1 group (basal diet supplemented with Xiao Jian Zhong prescriptions), and the TCM2 group (basal diet supplemented with Jingsananli-sepsis). The results showed that the contents of C3 and C4 in the serum were significantly increased in both the TCM1 and TCM2 groups compared to the Con group on day 30. Similarly, the levels of IgA, IgG, and IgM were increased in the TCM2 group, and only the level of IgM in TCM1 was increased on day 30. Meanwhile, the levels of classical swine fever virus (CSFV) and respiratory syndrome virus (PRRSV) antibodies had a notable increase in the TCM1 and TCM2 groups. Both TCM1 and TCM2 inhibited the levels of TLR4/MyD88/NF-κB signaling pathway-related mRNA (TLR4, MyD88, NF-κB, IL6, IL8, and TNF-α) and protein (p-IκBα and p-P65) expression levels in the thymus. In conclusion, dietary supplementation with TCM could reduce thymic inflammation levels and improve humoral immunity of finishing pigs.
Salah satu kegagalan konstruksi beton kebakaran pada konstruksi, hal ini mempengaruhi kualitas/kekuatan struktur beton. Beton mutu tinggi merupakan beton dengan kuat tekan lebih besar dari 41,4 Mpa. Pasir pozzolan dihasilkan dari alam hasil sedimentasi gunung berapi yang mengandung senyawa silika dan alumina seperti yang terkandung di dalam semen. Penelitian ini bertujuan untuk mengetahui berapa besar mutu kuat tekan beton pasca bakar dengan dan tanpa perendaman. Obyek dalam penelitian ini adalah beton segar menggunakan pasir pozzolan 10% sebagai pengganti sebagian agregat halus menggunakan superplasticizer 1,5% dari berat semen. Jumlah sampel pada penelitian ini 50 buah, 25 sampel Beton Normal dan 25 sampel Beton Pozzolan. Pengujian kuat tekan beton normal dan pasca bakar tanpa perendaman dilakukan pada umur 28 hari, sedangkan pada beton pasca bakar dengan perendaman dilakukan setelah 42 hari perendaman. Dari hasil penelitian diperoleh kuat tekan beton optimum mengunakan substitusi pasir pozzolan pasca bakar 200⁰C dengan perendaman sebesar 45,10 Mpa, sedangkan mutu beton yang terendah terdapat pada beton pasca bakar 400⁰C tanpa perendaman sebesar 31,97 Mpa. Penggunaan substitusi pasir pozzolan sebagai agregat halus terhadap beton pasca bakar dengan dan tanpa perendaman dapat meningkatkan mutu beton yang dibakar dengan suhu 200⁰C dan 400⁰C dibandingkan dengan beton normal pada perlakuan yang sama.
Objective: To investigate the efficacy and safety of limb ischemia preconditioning (LIPC) in the treatment of intradialytic hypotension (IDH) in patients with maintenance hemodialysis (MHD).
Methods: This was a single-center, prospective and randomized controlled case study. A total of 38 patients with MHD who met the inclusion criteria from September 2021 to August 2022 were selected from the Blood Purification Center of our hospital. They were randomly divided into the LIPC group (n = 19) and the control group (n = 19). For patients in the LIPC group, the femoral artery blood flow was blocked with an LIPC instrument for 5 min (pressurized to 200 mmHg) before each dialysis, and they were reperfused for 5 min. The cycle was repeated five times, with a total of 50 min for 12 weeks. The control group was pressurized to 20 mmHg with an LIPC instrument, and the rest was the same as the LIPC group. The blood pressure of 0h, 1h, 2h, 3h, 4h and body weight before and after hemodialysis were measured in the two groups during hemodialysis, the incidence of IDH and the changes of serum troponin I (TNI) and creatine kinase isoenzyme MB (CK-MB) levels before and after the intervention were observed, and the ultrafiltration volume and ultrafiltration rate were recorded.
Results: At the 8th and 12th week after intervention, the MAP in the LIPC group was higher than that in the control group (103.28 ± 12.19 vs. 93.18 ± 11.11, P=0.04;101.81 ± 11.36 vs. 91.81 ± 11.92,P=0.047). The incidence of IDH in the LIPC group was lower than that in the control group (36.5% vs. 43.1%, P=0.01). The incidence of clinical treatment in IDH patients in the LIPC group was lower than that in the control group (6.3% vs. 12.4%,P=0.00). The incidence of early termination of hemodialysis in the LIPC group was lower than that in the control group (1.6% vs. 3.8%, p = 0.01). The levels of TNI and CK-MB in the LIPC group after the intervention were lower than those in the control group (322.30±13.72vs.438.50±24.72, P=0.00; 159.78±8.48vs.207.00±8.70,P=0.00). The changes of MAP before and after the intervention were negatively correlated with the changes of TNI and CK-MB before and after the intervention (r = -0.473, P = 0.04; r =-0.469, P=0.04). There were no differences in dry body mass and ultrafiltration rate between the two groups before and after the LIPC intervention (P > 0.05). No LIPC-related adverse events were found during the study period.
Conclusion: LIPC can effectively reduce the incidence of IDH in patients with MHD, and may be associated with the alleviation of myocardial damage.
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