The cross dehydrogenation coupling reaction realizes direct coupling of two different X-H bonds to form a new chemical bond, thus featuring excellent step and atom economy. The traditional cross dehydrogenation coupling reaction was usually catalyzed by transition metal, which had the problems of expensive catalyst and serious pollution. Visible light-induced electron transfer is also an effective way to realize direct functionalization of X-H bonds. Visible-light-induced cross dehydrogenation coupling reaction under transition metal-free conditions is widely concerned due to the advantages of cleanliness, safety as well as high step and atom economy. Classified by the type of bonding, the research progress of these reactions is reviewed, and their future outlook is also discussed.
Selectfluor, a commercial electrophilic fluorination reagent with superior performance, is widely used in fluorination reactions. In recent years, Selectfluor has also been widely applied as "fluorine-free" functional reagent in organic synthesis. Especially the application of Selectfluor/transition metals synergetic catalytic system has made great progress. However, this catalytic system has some disadvantages, such as the use of expensive transition metals and environmental unfriendliness. Therefore, more and more attention has been paid to the application of Selectfluor as "fluorine-free" functional reagent under transition metal-free conditions. In this paper, classified by the type of reactions, the research progress of Selectfluor as a "fluorine-free" functional reagent in organic synthesis under transition metal-free conditions is reviewed, and their future outlook is also discussed.
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