Background: To describe the mechanisms of injury and the anatomo-clinical aspects of trauma caused by motorized two-wheeled vehicles at the Bouaké University Hospital. Methods: This was a retrospective descriptive study performed in the surgical emergency department of the Bouaké University Hospital. It lasted for a period of 08 months from February 1, 2015 to September 30, 2015. It concerned patients admitted to surgical emergencies for injuries that occurred during an accident involving a motorcycle. Neglected trauma due to accidents involving motorcycles, accident victims not involving motorcycles were not included in our study. The data collected were: age, sex, occupation, circumstances and mechanism of the accident, seat of the lesion and injury report. Results: During this study period, 2,647 emergency room patients were registered with 615 injuries due to motorcycle accidents. The frequency of road accidents caused by motorized two-wheelers accounted for 23.23% of surgical emergency room admissions. The average age of the victims was 31.9±16.7 years with extremes of 1 day and 95 years. There were 468 men (76.09%) and 147 women (23.91%), and the 21-30 age group was the most representative with (n=195, 31.70%) case. Students were the most affected (n=270, 43.91%) on traders (n=142, 23.09%). Motorcycle drivers (n=304, 49.44%) and motorcycle rear passengers (n=175, 28.45%) were the most affected. The most common types of accidents were motorcycle versus car (n=174, 28.29%), motorcycle versus pedestrian (n=154, 25.05%), and mishandled motorcycles (n=174; 143, 23.25%) of the cases. The majority of patients did not wear safety helmets (n=492, 80%). The lesions observed during our study sat preferentially at the limb level (n=344, 55.93%) and Skull n=115; 18.7%). Soft-tissue wounds (n=247, 40.15) predominated the cases, followed by fractures (n=145, 23.57%). There were eleven deaths (n=11, 1.79%). Conclusion: Road accidents due to two-wheeled vehicles (motorcycles) are more and more frequent in Bouaké. Motorcycle-to-car accidents are common. Deaths were due to head trauma in the majority of cases. Compliance with the Highway Code and mandatory use of a safety helmet could reduce the number and severity of injuries.