Conduct an accurate risk assessment of resected oral cavity squamous cell carcinoma (OSCC) patients by accessing a nationwide systemic investigation is pivotal to improve treatment outcomes. In this article, we tried to determine the impact of different prognostic factors for OSCC patients who received adjuvant radiotherapy (RT) after curative surgery, using Taiwan's national cancer registry database (TCR). A nationwide, large population‐based study was conducted using TCR with patients identified from 2007 to 2015. The study variables included age, gender, cancer subsites, stage, histology grade, margin and extra‐nodal extension (ENE) status, treatment type, surgery to RT interval (ORI), total RT treatment time (RTT), and RT dose. Univariate and multivariate analysis were performed to identify predictors of the variables associated with overall survival (OS), cause‐specific survival (CSS), local‐regional relapse‐free survival (LRFS), and distant metastasis‐free survival (DMFS). 8986 OSCC patients treated with surgery and adjuvant RT were analyzed. In multivariate analysis, worse outcomes were associated with males, older age, subsite in the oral tongue, advanced stage, higher histologic grade, involved margin, and positive ENE. ORI only showed an adverse trend in LRFS, when exceeding 7 weeks (P = .06). RTT >8 weeks was a significant poor predictor in OS, CSS and LRFS (P < .001). Extreme RT dose (>70 Gy or ≤50 Gy) also demonstrated an adverse impact on the outcomes. Prolonged RT treatment time and extreme RT doses were identified as significantly poor prognostic predictors in OSCC patients who received adjuvant RT after curative surgery.

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Mots-clé: Stabilité transitoire, Flexible alternating current transmission system (FACTS), Advanced static var compensator (ASVC), Commande floue, Commande neuro-floue.Cet article présente une étude sur l'influence d'un dispositif FACTS sur l'amélioration de la stabilité transitoire d'un système de puissance électrique. On se propose d'étudier dans ce travail deux méthodes de commande non linéaires. En premier lieu on va introduire, dans le système de commande, un régulateur flou de type PD. Par la suite, et pour une grande performance de réglage, le contrôleur flou sera remplacé par un régulateur neuro-flou. À la fin de cet article, une simulation numérique par ordinateur illustre les résultats obtenus en utilisant les deux types de réglage.

Serum neutrophil-to-lymphocytes ratio (NLR) is a potential predictive and prognostic marker in head and neck cancers. This study aimed to determine the role of pretreatment serum NLR in patients with hypopharyngeal cancer (HPC) treated with definitive chemoradiotherapy. We retrospectively investigated the correlation between clinicopathological parameters and NLR status and analysed its impact on therapeutic response and survival. A total of 120 patients treated at a single institution between 2009 and 2015 were included. The median follow-up time was 24.1 months. High NLR (NLR ≥ 4) was associated with advanced T classification (p = 0.01*) and advanced stage (p = 0.02*) based on chi-square test. We also found that high pretreatment NLR was correlated with poor treatment response (HR = 2.42, 95% CI: 1.08–5.44, p = 0.03*). Pretreatment NLR was also an independent prognostic factor for progression-free survival (HR = 1.71, 95% CI: 1.01–2.90, p = 0.046*) and overall survival (HR = 1.99, 95% CI: 1.21–3.28, p = 0.01*) while correcting for known prognostic factors. Overall, these findings support that NLR is a potential biomarker for host response to tumour aggressiveness, therapeutic response to chemoradiotherapy and survival in HPC patients. This study is limited by its retrospective nature and further validation is warranted.

A compliant mechanism transmits motion and force by deformation of its flexible members. It has no relative moving parts and thus involves no wear, lubrication, noise, and backlash. Compliant mechanisms aims to maximize flexibility while maintaining sufficient stiffness so that satisfactory output motion can be achieved. When designing compliant mechanisms, the resulting shapes sometimes lead to rigid-body type linkages where compliance and rotation is lumped at a few flexural pivots. These flexural pivots are prone to stress concentration and thus limit compliant mechanisms to applications that only require small-deflected motion. To overcome this problem, a systematic design method is presented to synthesize the shape of a compliant mechanism so that compliance is distributed more uniformly over the mechanism. With a selected topology and load conditions, this method characterizes the free geometric shape of a compliant segment by its rotation and thickness functions. These two are referred as intrinsic functions and they describe the shape continuously within the segment so there is no abrupt change in geometry. Optimization problems can be conveniently formulated with cusps and intersecting loops naturally circumvented. To facilitate the optimization process, a numerical algorithm based on the generalized shooting method will be presented to solve for the deflected shape. Illustrative examples will demonstrate that through the proposed design method, compliant mechanisms with distributed compliance will lessen stress concentration so they can be more robust and have larger deflected range. It is expected that the method can be applied to design compliant mechanisms that have a wide variety of applications from precision instruments to biomedical devices.