Cet article résume les connaissances principales sur les vaccins à ARN messager en septembre 2021. La seule contre-indication pour une 1 re dose de vaccin est une allergie à l'un des composants du vaccin, mais une consultation spécialisée est possible pour une éventuelle vaccination fractionnée sous surveillance médicale. Les effets secondaires graves sont rares et consistent principalement en myocardite, zona et appendicite, mais le rapport risques/ bénéfices est toujours favorable pour la vaccination. L'efficacité contre le Covid-19 sévère est supérieure à 90 % après 6 mois, et cela contre tous les variants. Il est recommandé de vacciner les femmes enceintes. Une 3 e dose n'est pas recommandée pour l'instant, sauf pour les personnes immunosupprimées sans anticorps détectables après 2 doses. Les mélanges de vaccins sont possibles, y compris avec un vaccin à vecteur viral. mRNA Covid vaccines: What do we know eight months after deployment This paper summarizes the main knowledge on mRNA vaccines in September 2021. The only contraindication for a 1st dose of vaccine is an allergy to one of the components of the vaccine, but a specia lized consultation is possible for an eventual split vaccination under medical supervision. Serious side effects are rare and consist mainly of myocarditis, shingles and appendicitis, but the risk/benefit ratio is always favorable for vaccination. Efficacy against severe COVID19 is > 90 % after 6 months, and this against all variants. It is recommended to vaccinate pregnant women. A 3rd dose is not recommended at this time, except for immunosuppressed individuals without detectable antibodies after 2 doses. Vaccine mixing is possible, including with a viral vector vaccine.
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