Serum AMH was significantly lower 2 days and 3 months following hysterectomy compared with the pre-operative level. Following myomectomy, serum AMH was significantly lower than the pre-operative level 2 days following the procedure, but was similar to the pre-operative level 3 months after surgery. Therefore, hysterectomy may have a more lasting adverse effect on ovarian reserve than myomectomy. A long-term study of AMH levels is needed.

The goal of this study was to analyze the relationships between self-esteem, perceived stress, the quality of different types of interpersonal relationships, and gender in adolescents. This study used a sample of 1614 adolescent high school students and robust data analytic techniques to test the proposed relationships. The results partially supported the initial hypothesis in that perceived stress mediated the relationships between self-esteem and four of the types of interpersonal relationships (i.e., same-sex peer relationships, opposite-sex peer relationships, parent-child relationships, and teacher-student relationships) and moderated the relationship between self-esteem and same-sex peer relationships. In addition, a moderated role of gender was also partially supported in that perceived stress mediated the relationships between self-esteem and same-sex peer relationships, opposite-sex peer relationships, and the parent-child relationship for girls, but not boys. On the basis of these findings, it was concluded that perceived stress plays an intervening role in the relationship between self-esteem and different types of interpersonal relationships and that gender seems to be a moderator for some of the patterns of the relationships between these variables. These findings are discussed in light of the possible mechanisms by which the variables could influence each other. Implications for theory and practice as well as some directions for future research were also suggested.

Weber & Hsee (1998) proposed the “cushion effect” as an explanation of the higher risk taking observed in some East Asian samples, relative to Western samples. Yates, Lee, & Shinotsuka (1992) proposed that the overconfidence observed in most Asian countries, relative to Western countries, reflects differences in the number of arguments typically recruited in those countries. This study examined the 2 seemingly separated domains of research: risk taking and overconfidence. It compared individual and collective (both family and group) decisions among Chinese in Singapore. This permitted tests of both the cushion and the argument recruitment hypotheses. The overall results obtained no support for the cushion effect and partial support for the argument recruitment hypotheses.

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The present study explored the effects of state overconfidence on persistent behavior with consideration of feasibility and desirability as mediators. The persistent behaviors of 61 participants (35 women, 26 men; M age = 20.9 yr, SD = 1.9), placed in overconfidence and under-confidence groups based on random positive or negative bogus feedback, were measured. Results showed that participants with overconfidence were more persistent in solving problems than were those with under-confidence. Further mediation analyses revealed that the rating of the feasibility rather than the desirability of the task mediated the influence of state overconfidence on persistent behaviors. These findings provided future support for the self-justification hypothesis, and addressed arguments regarding the origins of overconfidence.

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Background: Lung adenocarcinoma (LUAD) is a subtype of lung cancer (LC), which is the most common tumor worldwide. Accumulating evidence has elucidated an important role of microRNAs (miRNAs) in mediating the development and progression of several tumors. The purpose of this study was to explore the role and underlying mechanism of miR-15b in LUAD. Methods: CCK-8 and Transwell assays were conducted to measure the capacities of cell viability and migration in SPC-A1 cells. Luciferase assay was utilized to verifymiR-15b direct binding to BCL2 mRNA 3 0 -UTR. Results: We determined that miR-15b was overexpressed in LUAD and miR-15b overexpression predicted a significantly worse outcome in patients with LUAD. miR-15b improved LUAD growth in vitro and vivo. miR-15b enhanced cell migration and epithelial-mesenchymal transition (EMT) in LUAD. miR-15b promoted cell viability, migration and EMT through inhibiting BCL2 expression by targeting to its mRNA 3 0 -UTR. BCL2 reversed functions of miR-15b on promoting cell proliferation, migration and EMT in SPC-A1 cells. Conclusions: miR-15b promoted cell viability, migration and EMT by targeting BCL2 in LUAD. The newly identified miR-15b/BCL2 axis provides a novel insight into the pathogenesis of LUAD.

Tumor angiogenesis plays a crucial role in tumor growth, progression and metastasis, and suppression of tumor angiogenesis has been considered as a promising anticancer strategy. Salinomycin (SAL), an antibiotic, displays novel anticancer potential against several human cancer cells in vitro and in vivo. However, little information concerning its anti-angiogenic properties is available. Therefore, the anti-angiogenic effect of SAL and the underlying mechanism in human glioma were evaluated in the present study. The results indicated that SAL treatment significantly inhibited human umbilical vein endothelial cell (HUVEC) proliferation, migration, invasion and capillary-like tube formation. Further investigation on intracellular mechanisms showed that SAL markedly suppressed FAK and AKT phosphorylation, and downregulated vascular endothelial growth factor (VEGF) expression in HUVECs. Pretreatment of cells with a PI3K inhibitor (LY294002) and FAK inhibitor (PF562271) markedly enhanced SAL-induced inhibition of HUVEC proliferation and migration, respectively. Moreover, U251 human glioma xenograft growth was also effectively blocked by SAL treatment in vivo via inhibition of angiogenesis involving FAK and AKT depho sphorylation. Taken together, our findings validated that SAL inhibits angiogenesis and human glioma growth through suppression of the VEGF-VEGFR2-AKT/FAK signaling axis, indicating the potential application of SAL for the treatment of human glioma.