A tandem system enabled the synthesis of 2-substituted benzo[b]furans from 2-halophenols and aryl acetylenes was explored catalyzed by Ni/5-bromo-2,2’-dipyridine. The protocol could be effective for one-pot cascade coupling cyclization reaction producing benzo[b]furan compounds, and heteroaryl substrates was compatible to this system as well, giving corresponding products in 20-70% yields.
The first Ni-catalyzed tandem synthesis of 2-substituted benzo[b]furans/furo-pyridines from 2-halophenols and 1-alkynes was explored under Cu-free and phosphine-free conditions. The protocol was carried out with NiCl2/5-nitro-1, 10-phenanthroline in DMA (N,N-dimethylacetamide) at 120 °C. It was found to be simple, cost effective, and have a wide substrate scope. Additionally, the method is compatible with heteroaryl substrates, resulting in the formation of 2-substituted benzo[b]furans/furo-pyridines in reasonable to good yields.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.