Long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. However, the diagnostic values of most lncRNAs are largely unknown. To investigate whether gastric juice lncRNA-ABHD11-AS1 can be a potential biomarker in the screening of gastric cancer, 173 tissue samples and 130 gastric juice from benign lesion, gastric dysplasia, gastric premalignant lesions, and gastric cancer were collected. ABHD11-AS1 levels were detected by reverse transcription-polymerase chain reaction. Then, the relationships between ABHD11-AS1 levels and clinicopathological factors of patients with gastric cancer were investigated. The results showed that ABHD11-AS1 levels in gastric cancer tissues were significantly higher than those in other tissues. Its levels in gastric juice from gastric cancer patients were not only significantly higher than those from cases of normal mucosa or minimal gastritis, atrophic gastritis, and gastric ulcers but also associated with gender, tumor size, tumor stage, Lauren type, and blood carcinoembryonic antigen (CEA) levels. More importantly, when using gastric juice ABHD11-AS1 as a marker, the positive detection rate of early gastric cancer patients was reached to 71.4 %. Thanks to the special origin of gastric juice, these results indicate that gastric juice ABHD11-AS1 may be a potential biomarker in the screening of gastric cancer.
Gel
polymer electrolyte (GPE) is one of the most promising alternatives
to solve the bottlenecks of nonaqueous liquid electrolytes such as
decomposition, safety hazards, and growth of dendrites. In this work,
three novel methyl phosphonate-based crosslinking gel terpolymer electrolytes
with different comonomers are designed and prepared by in situ radical
polymerization. The gel polymer electrolytes have excellent thermal
stability, wide electrochemical windows (≥4.9 V), and high
ionic conductivities (±3 mS cm–1), and may
be used as less-flammable electrolytes for sodium-ion batteries. 31P NMR spectra, Arrhenius plot, and density functional theory
(DFT) calculations confirm that multifunctional phosphonate structural
units promote the dissociation of NaClO4 and help to transport
the sodium ions freely in the polymer framework. X-ray photoelectron
spectroscopy (XPS) results show that the gel polymer electrolytes
have the capability of inhibiting liquid electrolyte decomposition
and the formation of the stable solid electrolyte interphase (SEI)
film. The Na3V2(PO4)3/GPE/Na
cells exhibit better ultralong cycling stability and enhanced temperature
performance than those of liquid cells. Strikingly, GPE1 has the best comprehensive electrochemical performance, especially
the rate performance and long-term cycling stability with a capacity
retention ratio of 82.6% after 3500 cycles, which indicates that different
comonomers have obvious effects on the performance. Therefore, the
full cell of SnS2/GPE1/Na3V2(PO4)3 is evaluated and delivers good
cycling stability of 500 cycles, holding a great prospect for the
design and production of phosphorus-containing electrolytes for safer
sodium-ion batteries.
Using gel polymer electrolytes instead of liquid electrolytes is one of the methods to avoid safety hazards such as leakage, decomposition, and dendrite growth caused by conventional electrolytes. In this work, a series of functional monomers of methyl phosphonate with different flexible-group chain lengths are devised and synthesized. On the basis of these phosphonates, the gel copolymer electrolytes are obtained by in situ thermal copolymerization with trifluoroethyl methacrylate and methyl methacrylate. All gel copolymer electrolytes have excellent thermal stabilities, wide electrochemical stable windows (≥5.0 V vs Na/ Na + ), and adequate ionic conductivities (>1.4 × 10 −3 S cm −1 ), and the sodium ion conduction mechanism is discussed and supplemented by a theoretical calculation. The assembled Na 3 V 2 (PO 4 ) 3 /Na batteries with gel copolymer electrolytes all have better ultralong cycling stabilities than liquid cells with higher capacity retentions above 76% after 5000 cycles. Furthermore, the Na 3 V 2 (PO 4 ) 3 /GPE1−GPE3/Na batteries with shorter lengths of flexible-group chains have much better cycling stabilities and much higher capacity retentions up to 87% after 5000 cycles, and the Na 3 V 2 (PO 4 ) 3 /GPE1−GPE2/Na batteries with shorter lengths of flexible-group chains have better rate performance than GPE4-based batteries with longer chain lengths. In addition, the polarization properties, the interfacial compositions obtained by XPS, and the morphology characterizations of separators after cycling show that the gel polymer electrolytes with short-chain monomers have better interfacial stabilities and better capabilities of inhibiting decomposition of liquid electrolytes. In summary, the influence of multifunctional phosphonate monomers with different chain lengths on battery performance is studied in detail, and the structure−activity relationships of phosphonate-based gel polymer electrolytes are discussed. That provides a reference for the design and preparation of gel polymer electrolytes with better performance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.