A palladium-catalyzed
tandem carbonylative lactonization and Diels–Alder
cycloaddition reaction between aldehyde-tethered benzylhalides and
alkenes has been developed. A range of alkenes and aldehyde-tethered
benzylhalides bearing different substituents can be successfully transformed
into the corresponding bridged polycyclic compounds in good yields.
This strategy provides a unique approach to complex lactone-containing
bridged polycyclic compounds.
IntroductionSinonasal mucosal melanoma (SNMM) originates from melanocytes. Currently, the main treatment methods, including surgery, radiotherapy and chemotherapy, have little effect on the recurrence and metastasis of SNMM. However, targeted therapy may be a breakthrough in treating SNMM.MethodsA SNMM patient with ROS1 fusion received 250mg Crizotinib capsule (2 times a day, 1 tablet each time) therapy.ResultsThe patient achieved partial remission after 4 months of treatment and complete remission after 8 months of treatment.ConclusionOur findings suggest that crizotinib can be an option to improve overall survival and quality of life of patients with metastatic ROS1-fusion SNMM. We believe that our report will provide insights for the application of crizotini in the treatment of melanoma.
This paper proposes an improved Bacterial Foraging Optimization for economically optimal dispatching of the microgrid. Three optimized steps are presented to solve the slow convergence, poor precision, and low efficiency of traditional Bacterial Foraging Optimization. First, the self-adaptive step size equation in the chemotaxis process is present, and the particle swarm velocity equation is used to improve the convergence speed and precision of the algorithm. Second, the crisscross algorithm is used to enrich the replication population and improve the global search performance of the algorithm in the replication process. Finally, the dynamic probability and sine-cosine algorithm are used to solve the problem of easy loss of high-quality individuals in dispersal. Quantitative analysis and experiments demonstrated the superiority of the algorithm in the benchmark function. In addition, this study built a multi-objective microgrid dynamic economic dispatch model and dealt with the uncertainty of wind and solar using the Monte Carlo method in the model. Experiments show that this model can effectively reduce the operating cost of the microgrid, improve economic benefits, and reduce environmental pollution. The economic cost is reduced by 3.79% compared to the widely used PSO, and the economic cost is reduced by 5.23% compared to the traditional BFO.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.