Patients with moderate to severe plaque psoriasis, with or without psoriatic arthritis, have increased systemic inflammation demonstrated by elevated CRP levels. In psoriasis without psoriatic arthritis, skin disease activity is associated significantly with CRP elevation, independent of BMI, age and sex. Etanercept reduced CRP levels in all but the normal weight psoriasis group without psoriatic arthritis.
Acne vulgaris is as common in Taiwan as in Western countries. Ephelides are not uncommon in our population with the main skin types III-IV. A clustered distribution of the wart infection was noted. The low prevalence of AD in Taiwan seems unaltered over the past decade. AA and psoriasis are rare in our series. Most keloids in our children are caused by BCG vaccination.
Page 918: In the structure elucidation description for 6, "These enhancements revealed that the methyl and isolated methylene groups on the [3.1.0]bicyclohexyl moiety were cis oriented", should be corrected to "These enhancements revealed that the methyl and isolated methylene groups on the [3.1.0]bicyclohexyl moiety were trans oriented."The authors apologize for any inconvenience caused by these errors.
Background
RBM10ʹ
s function in hepatocellular carcinoma (HCC) has rarely been addressed. We intend to explore the prognostic significance and therapeutic meaning of
RBM10
in HCC in this study.
Methods
Multiple common databases were integrated to analyze the expression status and prognostic meaning of
RBM10
in HCC. The relationship between
RBM10
mRNA level and clinical features was also assessed. Multiple enrichment analyses of the differentially expressed genes between
RBM10
high- and low- transcription groups were constructed by using R software (version 4.0.2). A Search Tool for Retrieval of Interacting Genes database was used to construct the protein–protein interaction network between
RBM10
and other proteins. A tumor immune estimation resource database was employed to identify the relationship between
RBM10
expression and immune cell infiltrates. The prognostic value of
RBM10
expression was validated in our HCC cohort by immunohistochemistry test.
Results
The transcription of
RBM10
mRNA was positively correlated with tumor histologic grade (p < 0.001), T classification (p < 0.001), and tumor stage (p < 0.001). High transcription of
RBM10
in HCC predicted a dismal overall survival (p = 0.0037) and recurrence-free survival (p < 0.001). Kyoto Encyclopedia of Genes and Genomes, Gene Ontology, and Gene Set Enrichment Analysis all revealed that
RBM10
was involved in the regulation of cell cycle, DNA replication, and immune-related pathways. Tumor immune estimation analysis revealed that
RBM10
transcription was positively related to multiple immune cell infiltrates and the expressions of
PD-1
and
PD-L1
.
Conclusion
RBM10
was demonstrated to be a dismal prognostic factor and a potential biomarker for immune therapy in HCC in that it may be involved in the immune-related signaling pathways.
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