Congenic lines that differ in a single defined chromosome segment are useful for the study of complex phenotypes, as they allow isolation of the effect of a particular quantitative trait locus (QTL) from those of the entire genome. We conducted high-resolution QTL mapping of a 9-cM introgression, originating from the wild tomato species Lycopersicon pennellii, in two extremely different genetic and physiological backgrounds. In the "indeterminate" glasshouse background we identified only a single QTL ( Brix9-2-5) that affects the total soluble solids of the fruit [mainly sugars, measured in Brix units (B)]. This QTL was previously delimited within the gene for an apoplastic invertase, Lin5, that modulates sugar partitioning to the fruit. Analysis of the effects of the same chromosome segment in "determinate", open-field tomatoes, revealed two QTLs, 0.3 cM apart: the fruit-specific Brix9-2-5 that affects B only, and the shoot-specific PW9-2-5, which accounts for an altered growth habit resulting in increases in plant weight, yield, and B. This study highlights the power of the congenic approach for dissecting developmental pathways leading to complex phenotypes.

Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous clinical manifestations influenced by genetic and environmental factors. Five novel susceptibility genes (TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1) for SLE have been identified in a recent genome-wide association study of a Chinese Han population. This study investigated their relationships with disease subphenotypes, including renal nephritis, photosensitivity, antinuclear antibody (ANA), age at diagnosis, malar rash, discoid rash, immunological disorder, oral ulcer, hematological disorder, neurological disorder, serositis, arthritis and vasculitis. Significant associations were found for the single nucleotide polymorphism rs10036748 of TNIP1 with photosensitivity (odds ratio (OR) = 0.87, p = 0.01) and vasculitis (OR = 1.18, p = 0.04); rs10847697 of SLC15A4 with discoid rash (OR = 1.18, p = 0.02); rs6590330 of ETS1 with SLE of age at diagnosis <20 years (OR = 1.24, p = 8.91 x 10(-5)); rs13385731 of RasGRP3 with malar rash (OR = 1.20, p = 0.01), discoid rash (OR = 0.78, p = 0.02) and ANA (OR = 0.72, p = 0.004); rs4917014 of IKZF1 with renal nephritis (OR = 1.13, p = 0.02) and malar rash (OR = 0.83, p = 0.00038), respectively. The study suggested that these susceptibility genes might not only play important roles in the development of SLE, but also contribute to the complex phenotypes of SLE.

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The judgement of relative order (JOR) procedure is used to investigate serial-order memory. Measuring response times, the wording of the instructions (whether the earlier or the later item was designated as the target) reversed the direction of search in subspan lists (Chan, Ross, Earle, & Caplan Psychonomic Bulletin & Review, 16(5), 945-951, 2009). If a similar congruity effect applied to above-span lists and, furthermore, with error rate as the measure, this could suggest how to model order memory across scales. Participants performed JORs on lists of nouns (Experiment 1: list lengths = 4, 6, 8, 10) or consonants (Experiment 2: list lengths = 4, 8). In addition to the usual distance, primacy, and recency effects, instructions interacted with serial position of the later probe in both experiments, not only in response time, but also in error rate, suggesting that availability, not just accessibility, is affected by instructions. The congruity effect challenges current memory models. We fitted Hacker's (Journal of Experimental Psychology: Human Learning and Memory, 6(6), 651-675, 1980) self-terminating search model to our data and found that a switch in search direction could explain the congruity effect for short lists, but not longer lists. This suggests that JORs may need to be understood via direct-access models, adapted to produce a congruity effect, or a mix of mechanisms.

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Background and aims Cues associated with winning may encourage gambling. We assessed the effects on risky choice of slot machine of: (1) neutral sounds paired with winning, (2) casino‐related cues (such as the sound of coins dropping and pictures of dollar signs) and (3) relative payouts. Design Experimental studies in which participants repeatedly chose between safer and riskier simulated slot machines. Safer slot machines paid the same amount regardless of which symbols lined up. Risky machines paid different amounts depending on which symbols lined up. Effects of initially neutral sounds paired with the best payout were assessed between‐groups (experiment 1a) and within‐participants (experiment 1b). In experiment 2, pairing of casino‐related audiovisual cues with payout was assessed within participants, and cue timing was assessed between groups. Setting A university research laboratory in Edmonton, Canada. Participants Undergraduate students (n = 630 across three experiments). Measurements Preference for riskier over safer machines, preference between machines that differed in cues, payout recall and frequency estimates for payouts. Risky choice was calculated as the proportion of choices of the risky machine when presented with a fixed machine of the same expected value. Findings In experiment 1a, risky choice was slightly increased by pairing a sound with the best payout compared with pairing the sound with a lower payout (P = 0.04, d = 0.28) but not compared with no sound [P = 0.36, d = 0.13, Bayes factors (BF)10 = 0.22]. In experiment 1b, people did not prefer a machine with a best‐payout sound over one with a lower‐payout sound (P = 0.67, d = 0.03, BF10 = 0.11). Relative payout affected choice: risky choices were higher for high‐ than low‐payout decisions (P < 0.001, d = 0.53). In experiment 2, people preferred machines with casino‐related cues paired with winning (P < 0.001, r2 = 0.11) and cue timing (at choice or concurrently with the win) had no effect (P = 0.95, r2 = 0.0, BF10 = 0.05). Casino‐related cues also enhanced payout memory (P = 0.013 and 0.006). Cue effects were not specific to risk: people also preferred fixed‐payout machines with casino‐related cues (P < 0.001, r2 = 0.16). Conclusions In a gambling simulation, student participants chose more risky slot machines when payouts were relatively higher and when casino‐related cues were associated with payouts. Pairing a neutral sound with the best payout did not consistently affect slot machine choice, and the effect of casino cues did not depend on their timing. Casino‐related cues enhanced payout memory.

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