Background: Heart failure is the end stage of various heart diseases. For patients with poor or ineffective response drug treatment, heart transplantation is a reasonable and effective option. With the accumulation of heart transplantation cases, there are more and more studies on the immune response after heart transplantation. The purpose of the present study was to provide a bibliometric analysis of the current status of studies related to immune responses after heart transplantation.Methods: We searched the Science Citation Index Expanded online database with the following search terms: "heart transplantation" and "immune response". CiteSpace software was used to analyze the search results, including the annual trend in the number of publications, the annual trend in the number of citations, the distribution of the countries and institutions to which the authors belonged, the distribution of authors, the distribution of the journals that published the literature, and the use of keywords.Results: A total of 1,393 related research papers were included. The top five countries with the greatest number of published papers were the USA, China, Germany, the UK, and Japan. The countries with active cooperation with other countries were the USA, the UK, Germany, China, and Canada. The top five research institutions with the greatest number of published papers were the
Purpose: To compare the myocardial protective efficacy of del Nido cardioplegia (DNC) with St. Thomas blood cardioplegia (SBC) in adult cardiac surgery. Methods: From January to December 2021, all the patients who underwent elective cardiac operation were randomly divided into two cohorts based on the type of cardioplegia: DNC group and SBC group. Three categories of variables were compared: patient demographics, clinical variables, and laboratory variables. Results: A total of 133 patients were enrolled in this study: DNC group, n = 65; and SBC group, n = 68. Except that the volume of cardioplegia administration were obvious less in the DNC group (P <0.01), no significant difference was found in the other postoperative clinical variables (P >0.05). No statistical significance was proved (P >0.05) in postoperative troponin I, creatine kinase, and B-type natriuretic peptide. The malondialdehyde concentration was higher in the SBC group, whether it is at 4 hours (P <0.05) or 24 hours (P >0.05) after operation. At the same two points in time, the change in superoxide dismutase activity was more significant in the SBC group (P <0.05). Conclusion: The DNC cardioplegia was safe and effective on adult myocardium protection. The potential antioxidant stress effect in DNC may provide a direction for further improvement on the formula of cardioplegic solution.
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