A multifunctional targeted drug delivery platform (CDHA–MGO) has been successfully constructed by grafting β-cyclodextrin–hyaluronic acid polymers (CDHA) to Fe3O4–graphene oxide (MGO). The obtained CDHA–MGO nanocomposite has good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. The β-cyclodextrin-hyaluronic acid polymers efficaciously enhance the doxorubicin (DOX) loading amount up to 485.43 mg·g−1. Meanwhile, the Fe3O4–graphene oxide provides a facile photothermal response mechanism to handle the NIR-triggered release of DOX in weak acidic solvent environments. Significantly, the DOX-loaded nanocomposite (DOX@CDHA–MGO) has displayed CD44 receptor-mediated active targeting recognition and chemo-photothermal synergistic therapy of hepatoma cells. These findings suggest that the as-prepared drug delivery platform would be of valuable potential for cancer-targeted photo-chemotherapy.
A novel and very simple capillary electrophoretic method for analyzing aconitine components in Aconitum plants was developed using 1-butyl-3-methylimidazoium tetrafluoroborate (1B-3MI-TFB)-based ionic liquid as running electrolyte solution for the first time. The optimum conditions were 35 mM 1B-3MI-TFB solution (pH 8.50) and 15 kV applied voltage. The detection was performed at 254 nm. Aconitine, meaconitine and hypaconitine in Aconitum plants were separated and identified within 5 min. The recoveries were 91.0-103.0% for hypaconitine, 92.8-96.2% for aconitine and 96.0-106.6% for mesaconitine, respectively. Compared with other methods, the analytical time was decreased 4-8-fold and the effect of Joule heating was weaker because the current was smaller.
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