A series of novel 6-pyrazolinylcoumarins has been synthesized via multi-step protocol. The synthetic procedure was based on the acetylation of hydroxycoumarins; Fries rearrangement and Claisen-Schmidt condensation; the target 6-[5-aryl-4,5-dihydropyrazol-3-yl]-5-hydroxy-7-methylcoumarins () were obtained under reactions of hydrazine and 2-aryl-5-methyl-2,3-dihydropyrano[2,3-]chromen-4,8-diones as the last phase of the protocol. Anticancer activity screening in NCI60-cell lines assay allowed identification of compound with the highest level of antimitotic activity with mean GI value of 10.20 μM and certain sensitivity profile toward the Leukemia cell lines and (GI/TGI values 1.88/5.06 μM and 1.92/4.04 μM respectively).

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