It is desirable to have electromagnetic wave absorbers with ultrathin structural thickness and broader spectral absorption bandwidth with numerous applications in optoelectronics. In this paper, we theoretically propose and numerically demonstrate a novel ultrathin nanostructure absorber composed of semiconductor nanoring array and a uniform gold substrate. The results show that the absorption covers the entire visible light region, achieving an average absorption rate more than 90% in a wavelength range from 300 nm to 740 nm and a nearly perfect absorption from 450 nm to 500 nm, and the polarization insensitivity performance is particularly great. The absorption performance is mainly caused by the electrical resonance and magnetic resonance of semiconductor nanoring array as well as the field coupling effects. Our designed broadband visible light absorber has wide application prospects in the fields of thermal photovoltaics and photodetectors.
Dipyridamole, apart from its well-known antiplatelet and phosphodiesterase inhibitory activities, is a promising old drug for the treatment of pulmonary fibrosis. However, dipyridamole shows poor pharmacokinetic properties with a half-life (T1/2) of 7 min in rat liver microsomes (RLM). To improve the metabolic stability of dipyridamole, a series of pyrimidopyrimidine derivatives have been designed with the assistance of molecular docking. Among all the twenty-four synthesized compounds, compound (S)-4h showed outstanding metabolic stability (T1/2 = 67 min) in RLM, with an IC50 of 332 nM against PDE5. Furthermore, some interesting structure–activity relationships (SAR) were explained with the assistance of molecular docking.
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