Three flavonoids from tartary buckwheat bran, namely, quercetin (Que), isoquercetin (Iso) and rutin (Rut), have been evaluated as alpha-glucosidase inhibitors by fluorescence spectroscopy and enzymatic kinetics and have also been compared with the market diabetes healer, acarbose. The results indicated that Que, Iso and Rut could bind alpha-glucosidase to form a new complex, which exhibited a strong static fluorescence quenching via nonradiation energy transfer, and an obvious blue shift of maximum fluorescence. The sequence of binding constants (K(A)) was Que > Iso > Rut, and the number of binding sites was one for all of the three cases. The thermodynamic parameters were obtained by calculations based on data of binding constants. They revealed that the main driving force of the above-mentioned interaction was hydrophobic. Enzymatic kinetics measurements showed that all of the three compounds were effective inhibitors against alpha-glucosidase. Inhibitory modes all belonged to a mixed type of noncompetitive and anticompetitive. The sequence of affinity (1/K(i)) was in accordance with the results of binding constants (K(A)). The concentrations which gave 50% inhibition (IC(50)) were 0.017 mmol*L(-1), 0.185 mmol*L(-1) and 0.196 mmol*L(-1), compared with acarbose's IC(50) (0.091 mmol*L(-1)); the dose of acarbose was almost five times of that of Que and half of that of Iso and Rut. Our results explained why the inhibition on alpha-glucosidase of tartary buckwheat bran extractive substance (mainly Rut) was much weaker than that of its hydrolysis product (a mixture of Que, Iso and Rut). This work would be significant for the development of more powerful antidiabetes drugs and efficacious utilization of tartary buckwheat, which has been proved as an acknowledged food in the diet of diabetic patients.
A challenge method composed of digital image correlation (DIC) method, circle coordinate grid technology and finite element (FE) software to conduct strain measurement of bimetal is presented. This approach can carry out the prediction and measurement of strain. The coordinate grids are painted on top and bottom surface of bimetal when experiment and simulate specimen. Each node is named a fixed number in turn, and these numbers can precisely help to identify the same name point between FE software and the experiments specimen. The bimetal sheet has been tested using DIC software, circle center of the coordinates points can be accurately identify on the surface of bimetal. The changing of distance between adjacent points is computed to construct the forming limit diagram before and after forming. It is an effective means to evaluate the forming performance of bimetal and verify the reasonable of FE analysis results. 2A12 metal is conducted experiment using the challenge method in this paper, bimetal has not conduct experiment due to some reasons.
To be faced with the appearance and mechanical defects during refrigerator door making process, enterprises have no effective solutions. A springback prediction system is developed to accurately predict the springback of sheet metal and to improve die design. The main components, key theory and technique of this system are illustrated for the purpose of revealing co-relationship of springback and constitutive model and different parameters. It provides a powerful tool for cutting production cost and raising working efficiency. It is of great significence for engineers and enterprises.
The apparatus measuring apparent density was home-made by the studio; the apparatus, the measuring method and the working principle is introduced in this paper. The distribution of nano-magnetic particles in magnetic lubricating oil was measured by the homemade apparatus preliminarily, and the experimental results can lay a foundation for the research of tribological Performances in magnetic lubricating oil. Applied in the physical experimental teaching field, the apparatus enlarges the students field of visions and enables their creativity developed efficiently.
Since it is often appeared that connected-mold bearing FC208 rupture of roller foam machine in the production progress of a domestic company. A newly solve project on rupture of connected-mold bearing of roller foam machine based on finite element (FE) theory is put forward. All campaign process of this kind of machine is carried on mechanical analysis, and the maximum load force of bearing is calculated. FE models of FC208 and FC209 bearing are set up using ABAQUS software. The related simulation and analysis are conducted and force conditions of both components are compared with. The result of stress value is FC209 bearing is less than FC208 bearing. FC209 bearing is used in seven-positions rotating equipment made by ourselves in the company's No.40 # shop. The self-made equipment is running steady and reasonability of the improved design is proved.
The protocol of the hybrid server was designed based on the Internet of things for the realization of the intelligent management with the different equipments under the Internet of things. The Internet of things had large number of nodes, and the net topology was easy to change, it also had high requirements for the reliability. According to the properties of these properties, an efficient time-division multiple address protocol that was called E-TDMA protocol was proposed based on the improvement of the time division multiple address protocol. A power management system was designed based on the Internet of things, and the Internet of things was applied in the intelligent power management system, the indexes of the E-TDMA protocol based on the Internet of things such as throughput capacity, network stability were tested with the simulation. Test result shows that the number of the data packets in the buffer cache is much less than the traditional TDMA protocol and the dynamical TDMA protocol. It is because that the E-TDMA can make all the units can send data in the same time through CDMS coding. The result shows that the proposed E-TDMA protocol has efficient performance of accessing to the information channel and stability of network transmission in the application of the power management system.
In this paper, The benzene-ethanol extraction contents of the leaves, sprig and bark of eight different species on the Maoer Mountain region, the similarities and differences about the extraction contents of the different parts of the same species and the different tree species were studied, and attempted to analyze the reasons for the differences, in order to provide a reference for the fire tree species selection and forest fire prevention. The results showed that the extraction contents of leaves, sprig and bark parts of the same species did not differ greatly, the extraction contents of the different species showed significant difference, Korean Pine had the highest extraction content, Mandchur Ash and Manchurian Walnut Maxim had the lower extraction content, the variation range of the extraction contents was 8.01%~20.69%, and the extraction contents of the conifer species were significantly higher than the broad-leaved tree species. As far as benzene-ethanol extraction is concerned, Korean Pine was most burnt. Mandchur Ash and Manchurian Walnut Maxim was relative fire-retardant. And the conifers was more relatively easy to burn than the broad-leaved trees. The fire-retardant tree species could be considered as the fire protection tree species, such as, Mandchur Ash and Manchurian Walnut Maxim.
In order to improve the performance of the query optimization for the distribute database, an improved query optimization algorithm was proposed based on the genetic algorithm. The query execution cost model based on the genetic algorithm was proposed in this paper. The distributed database was emerged in the 70's of the last century and developed with the progress of the computer technology and network technology, the distributed database was the database system which is distributed storage dispersedly in physics and with centralized processing in mathematic logic. Because the storage points were not uniform, the structure of the distributed database is much more complicated than the centralized database. Both the genetic algorithm and the dynamic exhaustive planning algorithm were taken in the query simulation for the performance comparison. The result shows that the genetic query optimization method in this paper has better performance in the distributed database query application. The case study and the simulation result show that the algorithm can get a satisfactory optimization result in a few iterations and the query optimization algorithm based on the genetic method has nice performance of the query optimization property, and the consumption and costs of the query is reduced to the minimum. The method which this paper proposed has good application performance and is valuable to put into practice.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.