Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 1-5 to six new α-pyrone derivatives, xylapyrones A-F (compounds 6-11), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 1-3 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC50 values ranging from 25 to 63 μM and compounds 4-11 were found to be inactive, with IC50 values >100 μM.
The durability, such as chloride ion permeability, freeze-thaw and sulfate attack resistance of ultra-high performance concrete (UHPC) having a large amount, ranged from 42% to 48% by weight of binder, of mineral admixtures including steel slag powder (SS), ultrafine fly ash (UFFA) and silica fume (SF) was studied and the microstructure of selected UHPC compositions was investigated by Mercury porosimetry in this paper. Moreover, the relationship between durability and microstructure of UHPC was analyzed. The mercury porosimetry studies demonstrated the very low porosity and a high proportion of the innocuous pores as well as the very small pore size in UHPCs, whose most probable pore diameter did not exceed 10 nm. This porous structure of UHPCs would definitely enable the material have excellent durability.
Reactive powder concrete (RPC) is an ultra-high performance concrete (UHPC). Cement and silica fume content of RPC are generally rather high compared to the conventional concrete. The aim of this paper is to decrease the cement content of RPC by using phosphorous slag powder. Firstly the effect of grinding time on the activity index of phosphorous slag was investigated. And then, the mix proportion design of this UHPC containing phosphorous slag powder and silica fume was done through orthogonal design. The results indicate that the utilization of phosphorous slag powder in RPC is feasible when the dosage of phosphorous slag powder is about 35% (by weight of the binder) and the water-binder ratio is less than 0.18. By substituting phosphorous slag powder for a part of cement and keeping the water-binder ratio at about 0.14, UHPC specimens whose content of mineral admixtures, including phosphorous slag powder and silica fume, was about 40%~50% (by weight of the binder) were obtained after they had been cured in 80 °C water for 72 hours. The compressive and flexural strength of those specimens was more than 150 MPa and 20 MPa respectively.
The interfacial properties of reactive powder concretes (RPCs), other known as ultra-high performance concrete (UHPC), containing steel slag powder and ultra fine fly ash are studied in this paper. The microstrctural characterization of interfacial transition zones (ITZs), including the aggregate-cement paste interfacial zone and the steel fiber-paste interfacial zone, is investigated by SEM. The microhardness of the aggregate-paste ITZ and the steel slag-paste ITZ is studied and the bond strength of steel fiber in matrix is tested through fiber pullout tests. The results indicate that the microhardness of the steel slag-paste ITZ is slightly higher than that of the aggregate-paste ITZ, which implies the advantage of the substitution of quartz powder with steel slag powder in preparation of RPCs to some degrees. Moreover, the hardness of these two ITZs is higher than that of the hardened paste. A certain amount of hydration products has been observed exsiting on the surface of steel fiber by SEM and the bond strength of steel fiber-martix is up to 9.3MPa. These interfical properties are definitely critical to obtain high performance of UHPCs containing steel slag powder and fly ash.
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