Objective: Kawasaki disease (KD) is a multisystemic vasculitic disease that occasionally presents with gastrointestinal tract symptoms.Case presentation: A 2-year-old girl diagnosed with KD 4 months prior was referred to our hospital with complaints of vomiting. She was subsequently diagnosed with intussusception, which was efficiently alleviated through air insufflation. However, despite her improved clinical status, she had a fever unresponsive to antibiotic therapy. Four days later, the patient exhibited typical symptoms of Kawasaki disease. Thus, intravenous immunoglobulin and high-dose aspirin were administrated, and the outcome was satisfactory.Conclusions: In young children who present with crying, vomiting, and passage of bloody stools, color ultrasonography should be performed promptly to avoid missed diagnosis and misdiagnosis.
Introduction: In order to prevent COVID-19 from progressing, angiotensin-converting enzyme 2 (ACE2) binds to SARS-CoV-2 and prevents the virus from entering target cells. Several studies have found a correlation between COVID-19 risk and the ACE2 G8790A polymorphism; nevertheless, it remains inconclusive. A meta-analysis with relevant articles was carried out to more accurately estimate the risk of COVID-19.
Methodology: We conducted a systematic review using PubMed, Embase, Cochrane Library, Scopus, Science Direct and Web of Science databases. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. A meta-package was adopted in STATA version 12.0.
Results: It was concluded that the ACE2 G8790A polymorphism was not associated with COVID-19 based on the data collected. Moreover, subgroup analyses stratified based on race proved that the ACE2 G allele showed association with increasing risk of COVID-19 severity in Asians (G vs A: OR = 4.07, 95% CI = 3.19-5.19; GG vs AA: OR = 10.01, 95% CI = 5.39-18.56; GA vs AA: OR = 3.57, 95% CI = 1.84-6.93; dominant model: OR = 8.05, 95% CI = 4.36-14.88; recessive model: OR = 3.83, 95% CI = 2.89-5.08).
Conclusions: The findings indicated that the G allele of ACE2 G8790A was related to an enhanced risk of COVID-19 severity in Asians. One possible reason is that ACE2 G allele was associated with a COVID-19 cytokine storm. Furthermore, Asians have higher levels of ACE2 transcripts than Caucasians and Africans. Therefore, a genetic factor should be considered when developing vaccines in the future.
Objective: To analyze the depression status of pediatric standardized training residents in COVID-19.Methods: The depression status of pediatric residents undergoing standardized training at the First Affiliated Hospital of Yangtze University was investigated using the Self-rated Depression Scale (SDS). Statistical analysis was conducted using R version 3.5.3.Results: The prevalence of depression was found to be 66.6%. However, no significant statistical associations were observed between depression and various demographic factors, including gender, age, emotional status, educational background, possession of a professional doctor certificate, and monthly income.Conclusions: The incidence of depressive symptoms amongst pediatric residents undergoing standardized training during the COVID-19 pandemic is substantial, placing them at an elevated risk for depression.
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