Our findings provide the first evidence that depression may alter the function of killer lymphocytes in HIV-infected women and suggest that depression may decrease natural killer cell activity and lead to an increase in activated CD8 T lymphocytes and viral load. The rate of current major depression in these HIV-seropositive women (none of whom had current substance abuse) is approximately twice that reported for HIV-seropositive men. The rate is also consistent with studies of women with other medical illnesses and with a recent epidemiology study that associated depression with mortality in HIV-infected women with chronic depressive symptoms. Depression may have a negative impact on innate immunity. Examination of killer lymphocytes may prove useful in assessing the potential relationship between depression, immunity, and HIV disease progression in women.

unique effects of age, partner status, urological symptoms, depressive symptoms and pain. RESULTSUrinary scores, depressive symptoms and pain intensity scores significantly predicted QoL for patients with CP/CPPS (higher CPSI QoL scores indicated more impairment; median 8.0, range 0-12). On average, for every 1-point increase in urinary scores, there was a corresponding increase in QoL score of 0.118 points ( P = 0.001); for every 1-point increase in pain intensity score, there was a corresponding increase in QoL score of 0.722 points ( P < 0.001); and for every 1-point decrease in depressive symptoms (lower scores equal poorer mood), the QoL score increased (poorer quality of life) by 0.381 points ( P < 0.001). Age and partner status did not significantly contribute to poorer QoL. Urinary scores and depressive symptoms were significant predictors ( P < 0.001) of pain in patients with CP/CPPS. CONCLUSIONSThese data show that depressive symptoms and pain intensity significantly predict a poorer QoL in patients with CP/CPPS, and that these effects are independent of partner status, age and urinary status. In particular, pain intensity was the most robust predictor of a poorer QoL. Further data relating pain and psychological factors to CP/CPPS are highly recommended, to aid in determining specific factors for pain and its impact on QoL. These data are essential if empirically guided efforts to manage pain are to progress.

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Vanadium, a trace element in human cells and regarded as an essential nutrient, plays an active role in all tissues. It is known that peroxovanadate-nicotinic acid (POV), a complex compound of vanadium, can decrease hyperglycemia; however, its biochemical mechanism remains unclear. The object of the present study is to explore the hypoglycemia mechanism of POV at gene molecular levels. Rats rendered diabetic with streptozotocin were treated with POV. Total RNA was isolated from rat liver, and phenylalanine hydroxylase (PAH) mRNA abundance was determined by reverse transcriptase-polymerase chain reaction. PAH activity, blood glucose, and lipid levels were measured. Significantly increased hepatic PAH activity and corresponding mRNA with concomitant hyperglycemia and hyperlipemia were found in diabetic rats. These levels returned to normal after POV treatment and accompanied by negative glucosuria, normoglycemia, and normolipemia. The results from the current study indicates one of the mechanisms of POV action is to inhibit PAH gene expression and PAH activity, thus decreasing gluconeogenesis and hyperglycemia. At the same time, POV is able to promote diabetic recovery by lowering hyperlipemia.

Along with the rapid development of the science and technology, the requirements of microstructure and properties for the bearing steel are more and more strict. The recrystallization behavior of hot deformed austenite in GCr15 bearing steel was systematically studied under the different deformation amount, deformation temperature and dwell time after rolling, the changes of microstructure and recrystallization percentage was analyzed. The research results show that the recrystallization behavior of hot deformed austenite in GCr15 bearing steel is more and more obvious as the deformation amount, deformation temperature and dwell time after rolling increase, the microstructure is more uniform, and the recrystallization percentage increases; When the deformation amount is 20%, the deformation temperature is 850°C and the dwell time after rolling is 10s, the recrystallization percentage is 32.09%, when the deformation amount is 45%, the deformation temperature is 950°C and the dwell time after rolling is 60s, the recrystallization percentage is 64.31%, comparing it to 32.09%, it increases 100.4%.